Measuring Cot-Side the Effects of Parenteral Nutrition on Preterm Cortical Function

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Marchi , V , Stevenson , N , Koolen , N , Mazziotti , R , Moscuzza , F , Salvadori , S , Pieri , R , Ghirri , P , Guzzetta , A & Vanhatalo , S 2020 , ' Measuring Cot-Side the Effects of Parenteral Nutrition on Preterm Cortical Function ' , Frontiers in Human Neuroscience , vol. 14 , 69 .

Title: Measuring Cot-Side the Effects of Parenteral Nutrition on Preterm Cortical Function
Author: Marchi, Viviana; Stevenson, Nathan; Koolen, Ninah; Mazziotti, Raffaele; Moscuzza, Francesca; Salvadori, Stefano; Pieri, Rossella; Ghirri, Paolo; Guzzetta, Andrea; Vanhatalo, Sampsa
Contributor organization: HUS Medical Imaging Center
Department of Neurosciences
Children's Hospital
HUS Children and Adolescents
Helsinki University Hospital Area
Kliinisen neurofysiologian yksikkö
Date: 2020-03-17
Language: eng
Number of pages: 10
Belongs to series: Frontiers in Human Neuroscience
ISSN: 1662-5161
Abstract: Early nutritional compromise after preterm birth is shown to affect long-term neurodevelopment, however, there has been a lack of early functional measures of nutritional effects. Recent progress in computational electroencephalography (EEG) analysis has provided means to measure the early maturation of cortical activity. Our study aimed to explore whether computational metrics of early sequential EEG recordings could reflect early nutritional care measured by energy and macronutrient intake in the first week of life. A higher energy or macronutrient intake was assumed to associate with improved development of the cortical activity. We analyzed multichannel EEG recorded at 32 weeks (32.4 ± 0.7) and 36 weeks (36.6 ± 0.9) of postmenstrual age in a cohort of 28 preterm infants born before 32 weeks of postmenstrual age (range: 24.3–32 weeks). We computed several quantitative EEG measures from epochs of quiet sleep (QS): (i) spectral power; (ii) continuity; (iii) interhemispheric synchrony, as well as (iv) the recently developed estimate of maturational age. Parenteral nutritional intake from day 1 to day 7 was monitored and clinical factors collected. Lower calories and carbohydrates were found to correlate with a higher reduction of spectral amplitude in the delta band. Lower protein amount associated with higher discontinuity. Both higher proteins and lipids intake correlated with a more developmental increase in interhemispheric synchrony as well as with better progress in the estimate of EEG maturational age (EMA). Our study shows that early nutritional balance after preterm birth may influence subsequent maturation of brain activity in a way that can be observed with several intuitively reasoned and transparent computational EEG metrics. Such measures could become early functional biomarkers that hold promise for benchmarking in the future development of therapeutic interventions.
Subject: 3112 Neurosciences
preterm nutrition
functional biomarker
neonatal EEG
preterm infant
neonatal intensive care unit
brain monitoring
computational EEG analysis
3124 Neurology and psychiatry
515 Psychology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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