Elevated Systemic IL-10 Levels Indicate Immunodepression Leading to Nosocomial Infections after Aneurysmal Subarachnoid Hemorrhage (SAH) in Patients

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Chaudhry , S R , Kahlert , U D , Kinfe , T M , Lamprecht , A , Niemelä , M , Hänggi , D & Muhammad , S 2020 , ' Elevated Systemic IL-10 Levels Indicate Immunodepression Leading to Nosocomial Infections after Aneurysmal Subarachnoid Hemorrhage (SAH) in Patients ' , International Journal of Molecular Sciences , vol. 21 , no. 5 , 1569 . https://doi.org/10.3390/ijms21051569

Title: Elevated Systemic IL-10 Levels Indicate Immunodepression Leading to Nosocomial Infections after Aneurysmal Subarachnoid Hemorrhage (SAH) in Patients
Author: Chaudhry, Shafqat Rasul; Kahlert, Ulf Dietrich; Kinfe, Thomas Mehari; Lamprecht, Alf; Niemelä, Mika; Hänggi, Daniel; Muhammad, Sajjad
Contributor organization: Department of Neurosciences
HUS Neurocenter
Neurokirurgian yksikkö
University of Helsinki
Helsinki University Hospital Area
Clinicum
Date: 2020-03
Language: eng
Number of pages: 13
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms21051569
URI: http://hdl.handle.net/10138/315260
Abstract: Background: Aneurysmal subarachnoid hemorrhage (SAH) is a highly complex disease with very high mortality and morbidity. About one-third of SAH patients suffer from systemic infections, predominantly pneumonia, that can contribute to excess mortality after SAH. Immunodepression is probably the most important mechanism leading to infections. Interleukin-10 (IL-10) is a master regulator of immunodepression, but it is still not clear if systemic IL-10 levels contribute to immunodepression, occurrence of infections and clinical outcome after SAH. Methods: This explorative study included 76 patients with SAH admitted to our neurointensive care unit within 24 h after ictus. A group of 24 patients without any known intracranial pathology were included as controls. Peripheral venous blood was withdrawn on day 1 and day 7 after SAH. Serum was isolated by centrifugation and stored at -80 degrees C until analysis. Serum IL-10 levels were determined by enzyme-linked immunoassay (ELISA). Patient characteristics, post-SAH complications and clinical outcome at discharge were retrieved from patients' record files. Results: Serum IL-10 levels were significantly higher on day 1 and day 7 in SAH patients compared to controls. Serum IL-10 levels were significantly higher on day 7 in patients who developed any kind of infection, cerebral vasospasm (CVS) or chronic hydrocephalus. Serum IL-10 levels were significantly higher in SAH patients discharged with poor clinical outcome (modified Rankin Scale (mRS) 3-6 or Glasgow Outcome Scale (GOS) 1-3). Conclusion: Serum IL-10 might be an additional useful parameter along with other biomarkers to predict post-SAH infections.
Subject: subarachnoid hemorrhage
cytokine
anti-inflammatory
early brain injury
stroke
aneurysm
inflammation
cerebral vasospasm
clinical outcome
complications
CEREBROSPINAL-FLUID
INTERLEUKIN-10
PREDICTORS
CYTOKINES
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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