Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

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Asghar , M Y & Törnquist , K 2020 , ' Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion ' , International Journal of Molecular Sciences , vol. 21 , no. 5 , 1739 . https://doi.org/10.3390/ijms21051739

Title: Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
Author: Asghar, Muhammad Yasir; Törnquist, Kid
Contributor organization: Medicum
Date: 2020-03
Language: eng
Number of pages: 15
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms21051739
URI: http://hdl.handle.net/10138/315263
Abstract: Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1-7. In man, six functional forms are expressed (TRPC1, TRPC3-7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion.
Subject: TRPC
ion channels
cancer
thyroid
calcium
migration
invasion
angiogenesis
CA2+ ENTRY
CELL-PROLIFERATION
ION CHANNELS
ENDOTHELIAL-CELLS
EPITHELIAL-CELLS
IN-VITRO
CALCIUM
STORE
CANCER
EXPRESSION
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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