Ligthart , K , Belzer , C , de Vos , W M & Tytgat , H L P 2020 , ' Bridging Bacteria and the Gut: Functional Aspects of Type IV Pili ' , Trends in Microbiology , vol. 28 , no. 5 , pp. 340-348 . https://doi.org/10.1016/j.tim.2020.02.003
Title: | Bridging Bacteria and the Gut: Functional Aspects of Type IV Pili |
Author: | Ligthart, Kate; Belzer, Clara; de Vos, Willem M.; Tytgat, Hanne L.P. |
Contributor organization: | Willem Meindert Vos de / Principal Investigator de Vos & Salonen group Research Programs Unit HUMI - Human Microbiome Research Faculty of Medicine University of Helsinki |
Date: | 2020-05 |
Language: | eng |
Number of pages: | 9 |
Belongs to series: | Trends in Microbiology |
ISSN: | 0966-842X |
DOI: | https://doi.org/10.1016/j.tim.2020.02.003 |
URI: | http://hdl.handle.net/10138/315270 |
Abstract: | Cell-surface-located proteinaceous appendages, such as flagella and fimbriae or pili, are ubiquitous in bacterial communities. Here, we focus on conserved type IV pili (T4P) produced by bacteria in the intestinal tract, one of the most densely populated human ecosystems. Computational analysis revealed that approximately 30% of known intestinal bacteria are predicted to produce T4P. To rationalize how T4P allow intestinal bacteria to interact with their environment, other microbiota members, and host cells, we review their established role in gut commensals and pathogens with respect to adherence, motility, and biofilm formation, as well as protein secretion and DNA uptake. This work indicates that T4P are widely spread among the known members of the intestinal microbiota and that their contribution to human health might be underestimated. |
Subject: |
3111 Biomedicine
11832 Microbiology and virology type IV pili fimbriae microbiome commensal pathogen microbiota–host interactions NATURAL TRANSFORMATION AERUGINOSA MINOR PILINS COLONIZATION BIOGENESIS ENTEROPATHOGENIC ESCHERICHIA-COLI SECRETION RETRACTION PROTEINS BINDING DOMAINS |
Peer reviewed: | Yes |
Rights: | cc_by_nc_nd |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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