Bridging Bacteria and the Gut: Functional Aspects of Type IV Pili

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Ligthart , K , Belzer , C , de Vos , W M & Tytgat , H L P 2020 , ' Bridging Bacteria and the Gut: Functional Aspects of Type IV Pili ' , Trends in Microbiology , vol. 28 , no. 5 , pp. 340-348 . https://doi.org/10.1016/j.tim.2020.02.003

Title: Bridging Bacteria and the Gut: Functional Aspects of Type IV Pili
Author: Ligthart, Kate; Belzer, Clara; de Vos, Willem M.; Tytgat, Hanne L.P.
Contributor: University of Helsinki, Willem Meindert Vos de / Principal Investigator
Date: 2020-05
Language: eng
Number of pages: 9
Belongs to series: Trends in Microbiology
ISSN: 0966-842X
URI: http://hdl.handle.net/10138/315270
Abstract: Cell-surface-located proteinaceous appendages, such as flagella and fimbriae or pili, are ubiquitous in bacterial communities. Here, we focus on conserved type IV pili (T4P) produced by bacteria in the intestinal tract, one of the most densely populated human ecosystems. Computational analysis revealed that approximately 30% of known intestinal bacteria are predicted to produce T4P. To rationalize how T4P allow intestinal bacteria to interact with their environment, other microbiota members, and host cells, we review their established role in gut commensals and pathogens with respect to adherence, motility, and biofilm formation, as well as protein secretion and DNA uptake. This work indicates that T4P are widely spread among the known members of the intestinal microbiota and that their contribution to human health might be underestimated.
Subject: 3111 Biomedicine
11832 Microbiology and virology
type IV pili
fimbriae
microbiome
commensal
pathogen
microbiota–host interactions
NATURAL TRANSFORMATION
AERUGINOSA MINOR PILINS
COLONIZATION
BIOGENESIS
ENTEROPATHOGENIC ESCHERICHIA-COLI
SECRETION
RETRACTION
PROTEINS
BINDING
DOMAINS
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