Association between local immune cell infiltration, mismatch repair status and systemic inflammatory response in colorectal cancer

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Gunnarsson , U , Strigård , K , Edin , S , Gkekas , I , Mustonen , H , Kaprio , T , Böckelman , C , Hagström , J , Palmqvist , R & Haglund , C 2020 , ' Association between local immune cell infiltration, mismatch repair status and systemic inflammatory response in colorectal cancer ' , Journal of Translational Medicine , vol. 18 , no. 1 , 178 . https://doi.org/10.1186/s12967-020-02336-6

Title: Association between local immune cell infiltration, mismatch repair status and systemic inflammatory response in colorectal cancer
Author: Gunnarsson, Ulf; Strigård, Karin; Edin, Sofia; Gkekas, Ioannis; Mustonen, Harri; Kaprio, Tuomas; Böckelman, Camilla; Hagström, Jaana; Palmqvist, Richard; Haglund, Caj
Contributor organization: HUS Abdominal Center
Clinicum
Department of Surgery
University of Helsinki
Helsinki University Hospital Area
CAN-PRO - Translational Cancer Medicine Program
Faculty of Medicine
Research Programs Unit
Medicum
Department of Pathology
II kirurgian klinikka
HUSLAB
Date: 2020-04-21
Language: eng
Number of pages: 8
Belongs to series: Journal of Translational Medicine
ISSN: 1479-5876
DOI: https://doi.org/10.1186/s12967-020-02336-6
URI: http://hdl.handle.net/10138/315436
Abstract: Systemic inflammatory response in colorectal cancer (CRC) has been established as a prognostic factor for impaired cancer-specific survival, predominantly in patients with right-sided tumors. On the other hand, defective mismatch repair (dMMR) tumors, primarily located in the right colon, are known to have favorable survival and dense local immune infiltration. The aim of this study was to see if there is any form of relationship between these seemingly diverse entities.
Subject: 3122 Cancers
Colorectal cancer
Local immune response
Systematic inflammatory response
Miscrosatellite instability
Mismatch repair
C-REACTIVE PROTEIN
COLON
RECURRENCE
PROGNOSIS
RESECTION
SURVIVAL
SURGERY
3111 Biomedicine
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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