Predicting tablet tensile strength with a model derived from the gravitation-based high-velocity compaction analysis data

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http://hdl.handle.net/10138/315438

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Tanner , T , Antikainen , O , Pollet , A , Räikönen , H , Ehlers , H , Juppo , A & Yliruusi , J 2019 , ' Predicting tablet tensile strength with a model derived from the gravitation-based high-velocity compaction analysis data ' , International Journal of Pharmaceutics , vol. 566 , pp. 194-202 . https://doi.org/10.1016/j.ijpharm.2019.05.024

Title: Predicting tablet tensile strength with a model derived from the gravitation-based high-velocity compaction analysis data
Author: Tanner, Timo; Antikainen, Osmo; Pollet, Arne; Räikönen, Heikki; Ehlers, Henrik; Juppo, Anne; Yliruusi, Jouko
Contributor: University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Divisions of Faculty of Pharmacy
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Pharmaceutical Design and Discovery group
University of Helsinki, Divisions of Faculty of Pharmacy
Date: 2019-07-20
Language: eng
Number of pages: 9
Belongs to series: International Journal of Pharmaceutics
ISSN: 0378-5173
URI: http://hdl.handle.net/10138/315438
Abstract: In the present study, a model was developed to estimate tablet tensile strength utilizing the gravitation-based high-velocity (G-HVC) method introduced earlier. Three different formulations consisting of microcrystalline cellulose (MCC), dicalcium phosphate dihydrate (DCP), hydroxypropyl methylcellulose (HPMC), theophylline and magnesium stearate were prepared. The formulations were granulated using fluid bed granulation and the granules were compacted with the G-HVC method and an eccentric tableting machine. Compaction energy values defined from G-HVC data predicted tensile strength of the tablets surprisingly well. It was also shown, that fluid bed granulation improved the compaction energy intake of the granules in comparison to respective physical mixtures. In addition, general mechanical properties and elastic recovery were also examined for all samples. In this study it was finally concluded, that the data obtained by the method was of practical relevance in pharmaceutical formulation development.
Subject: Powders
Tablets
Compression
Compaction
Tabletability
Tensile strength
Elastic recovery
DICALCIUM PHOSPHATE DIHYDRATE
MICROCRYSTALLINE CELLULOSE
WET GRANULATION
DIRECT COMPRESSION
PARTICLE-SIZE
PHARMACEUTICAL POWDERS
MECHANICAL-PROPERTIES
CAPPING TENDENCY
ELASTIC RECOVERY
BINARY-MIXTURE
317 Pharmacy
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