Phylogenomic Analysis of Secondary Metabolism in the Toxic Cyanobacterial Genera Anabaena, Dolichospermum and Aphanizomenon

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Osterholm , J , Popin , R V , Fewer , D P & Sivonen , K 2020 , ' Phylogenomic Analysis of Secondary Metabolism in the Toxic Cyanobacterial Genera Anabaena, Dolichospermum and Aphanizomenon ' , Toxins , vol. 12 , no. 4 , 248 . https://doi.org/10.3390/toxins12040248

Title: Phylogenomic Analysis of Secondary Metabolism in the Toxic Cyanobacterial Genera Anabaena, Dolichospermum and Aphanizomenon
Author: Osterholm, Julia; Popin, Rafael V.; Fewer, David P.; Sivonen, Kaarina
Contributor: University of Helsinki, Cyanobacteria research
University of Helsinki, Department of Microbiology
University of Helsinki, Department of Microbiology
University of Helsinki, Department of Microbiology
Date: 2020-04
Language: eng
Number of pages: 16
Belongs to series: Toxins
ISSN: 2072-6651
URI: http://hdl.handle.net/10138/315748
Abstract: Cyanobacteria produce an array of toxins that pose serious health risks to humans and animals. The closely related diazotrophic genera, Anabaena, Dolichospermum and Aphanizomenon, frequently form poisonous blooms in lakes and brackish waters around the world. These genera form a complex now termed the Anabaena, Dolichospermum and Aphanizomenon (ADA) clade and produce a greater array of toxins than any other cyanobacteria group. However, taxonomic confusion masks the distribution of toxin biosynthetic pathways in cyanobacteria. Here we obtained 11 new draft genomes to improve the understanding of toxin production in these genera. Comparison of secondary metabolite pathways in all available 31 genomes for these three genera suggests that the ability to produce microcystin, anatoxin-a, and saxitoxin is associated with specific subgroups. Each toxin gene cluster was concentrated or even limited to a certain subgroup within the ADA clade. Our results indicate that members of the ADA clade encode a variety of secondary metabolites following the phylogenetic clustering of constituent species. The newly sequenced members of the ADA clade show that phylogenetic separation of planktonic Dolichospermum and benthic Anabaena is not complete. This underscores the importance of taxonomic revision of Anabaena, Dolichospermum and Aphanizomenon genera to reflect current phylogenomic understanding.
Subject: 11832 Microbiology and virology
cyanobacteria
biosynthetic gene cluster
cyanotoxin
microcystin
anatoxin
natural products
phylogenomics
DNA-DNA HYBRIDIZATION
COMPARATIVE GENOMICS
GET-HOMOLOGS
STRAINS
CLUSTER
BLOOM
DIVERSITY
MODELS
CYLINDROSPERMOPSIN
IDENTIFICATION
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