Histopathological features of epithelioid malignant pleural mesotheliomas in patients with extended survival

Show full item record



Permalink

http://hdl.handle.net/10138/315810

Citation

Paajanen , J , Laaksonen , S , Kettunen , E , Ilonen , I , Vehmas , T , Salo , J , Räsänen , J , Sutinen , E , Ollila , H , Mäyränpää , M I , Myllärniemi , M & Wolff , H 2020 , ' Histopathological features of epithelioid malignant pleural mesotheliomas in patients with extended survival ' , Human Pathology , vol. 98 , pp. 110-119 . https://doi.org/10.1016/j.humpath.2020.02.007

Title: Histopathological features of epithelioid malignant pleural mesotheliomas in patients with extended survival
Author: Paajanen, Juuso; Laaksonen, Sanna; Kettunen, Eeva; Ilonen, Ilkka; Vehmas, Tapio; Salo, Jarmo; Räsänen, Jari; Sutinen, Eva; Ollila, Hely; Mäyränpää, Mikko I.; Myllärniemi, Marjukka; Wolff, Henrik
Contributor: University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUSLAB
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Clinicum
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUSLAB
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Medicum
Date: 2020-04
Language: eng
Number of pages: 10
Belongs to series: Human Pathology
ISSN: 0046-8177
URI: http://hdl.handle.net/10138/315810
Abstract: Diffuse malignant mesothelioma (DMM) of the pleura is a rare and aggressive disease, where the long-term survival (LTS) rate is low. The epithelioid subtype is the most prevalent form of DMM with the best prognosis. In order to study prognostic histopathologic factors associated with extended survival in epithelioid DMM, we examined 43 tumors from patients with survival over five years (long-term survivals [LTS]) and compared the findings with 84 tumors from a reference group with average survival (RG). We analyzed the tumors considering previously published histopathological prognostic features and attempted to identify additional morphological features predictive of extended survival. Most of the LTS tumors presented with nuclear grade I (n = 34,90%) and a tubulopapillary growth pattern (n = 30,70%). One LTS tumor had necrosis. In contrast, nuclear grade II (n = 49,61%) and solid growth pattern (n = 59,70%) were more frequent in RG, and necrosis was present in 16 (19%) tumors. We also evaluated the association of asbestos lung tissue fiber burden quantified from autopsy samples with histopathological features and found that elevated asbestos fiber was associated with higher nuclear grade (p <0.001) and the presence of necrosis (p = 0.021). In univariate survival analysis, we identified the following three novel morphological features associated with survival: exophytic polypoid growth pattern, tumor density, and single mesothelium layered tubular structures. After adjustments, low nuclear grade (p <0.001) and presence of exophytic polypoid growth (p = 0.024) were associated with prolonged survival. These results may aid in estimating DMM prognosis.
Subject: 3121 General medicine, internal medicine and other clinical medicine
epithelioid mesothelioma
histopathology
survival
grade
asbestos
DIAGNOSIS
PREDICTS
Epithelioid mesothelioma
Asbestos
MANAGEMENT
Grade
DIFFERENTIATED PAPILLARY MESOTHELIOMA
HYPERPLASIA
Survival
GRADING SYSTEM
Histopathology
NECROSIS
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0046817720300484_main.pdf 12.34Mb PDF View/Open
1_s2.0_S0046817720300484_main.pdf 1.937Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record