Pan-cancer analysis of whole genomes

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Campbell , P J , Getz , G , Korbel , J O , Stuart , J M , Jennings , J L , Stein , L D , Perry , M D , Nahal-Bose , H K , Ouellette , B F F , Li , C H , Rheinbay , E , Nielsen , G P , Sgroi , D C , Wu , C-L , Faquin , W C , Deshpande , V , Boutros , P C , Lazar , A J , Hoadley , K A , Louis , D N , Dursi , L J , Yung , C , Bailey , M H , Saksena , G , Raine , K M , Buchhalter , I , Kleinheinz , K , Schlesner , M , Zhang , J , Wang , W , Wheeler , D A , Ding , L , Simpson , J T , O'Connor , B D , Yakneen , S , Ellrott , K , Miyoshi , N , Butler , A P , Royo , R , Shorser , S , Vazquez , M , Rausch , T , Tiao , G , Waszak , S M , Rodriguez-Martin , B , Shringarpure , S , Wu , D-Y , Demidov , G M , Delaneau , O , Hayashi , S , Imoto , S , Habermann , N , Segre , A , Garrison , E , Cafferkey , A , Alvarez , E G , Maria Heredia-Genestar , J , Muyas , F , Drechsel , O , Bruzos , A L , Temes , J , Zamora , J , Baez-Ortega , A , Kim , H-L , Mashl , R J , Ye , K , DiBiase , A , Huang , K , Letunic , I , McLellan , M D , Newhouse , S J , Shmaya , T , Kumar , S , Wedge , D C , Wright , M H , Yellapantula , V D , Gerstein , M , Khurana , E , Marques-Bonet , T , Navarro , A , Bustamante , C D , Siebert , R , Nakagawa , H , Easton , D F , Ossowski , S , Tubio , J M C , De La Vega , F M , Estivill , X , Yuen , D , Mihaiescu , G L , Omberg , L , Ferretti , V , Sabarinathan , R , Pich , O , Gonzalez-Perez , A , Weiner , A T , Fittall , M W , Demeulemeester , J , Tarabichi , M , Roberts , N D , Van Loo , P , Cortes-Ciriano , I , Urban , L , Park , P , Bin Zhu , L , Pitkaenen , E , Li , Y , Saini , N , Klimczak , L J , Weischenfeldt , J , Sidiropoulos , N , Alexandrov , L B , Rabionet , R , Escaramis , G , Bosio , M , Holik , A Z , Susak , H , Prasad , A , Erkek , S , Calabrese , C , Raeder , B , Harrington , E , Mayes , S , Turner , D , Juul , S , Roberts , S A , Song , L , Koster , R , Mirabello , L , Hua , X , Tanskanen , T J , Tojo , M , Chen , J , Aaltonen , L A , Ratsch , G , Schwarz , R F , Butte , A J , Brazma , A , Chanock , S J , Chatterjee , N , Stegle , O , Harismendy , O , Bova , G S , Gordenin , D A , Haan , D , Sieverling , L , Feuerbach , L , Chalmers , D , Joly , Y , Knoppers , B M , Molnar-Gabor , F , Phillips , M , Thorogood , A , Townend , D , Goldman , M , Fonseca , N A , Xiang , Q , Craft , B , Pineiro-Yanez , E , Munoz , A , Petryszak , R , Fullgrabe , A , Al-Shahrour , F , Keays , M , Haussler , D , Weinstein , J , Huber , W , Valencia , A , Papatheodorou , I , Zhu , J , Fan , Y , Torrents , D , Bieg , M , Chen , K , Chong , Z , Cibulskis , K , Eils , R , Fulton , R S , Gelpi , J L , Gonzalez , S , Gut , I G , Hach , F , Heinold , M , Hu , T , Huang , V , Hutter , B , Jaeger , N , Jung , J , Kumar , Y , Lalansingh , C , Leshchiner , I , Livitz , D , Ma , E Z , Maruvka , Y E , Milovanovic , A , Nielsen , M M , Paramasivam , N , Pedersen , J S , Puiggros , M , Sahinalp , S C , Sarrafi , I , Stewart , C , Stobbe , M D , Wala , J A , Wang , J , Wendl , M C , Werner , J , Wu , Z , Xue , H , Yamaguchi , T N , Yellapantula , V , Davis-Dusenbery , B N , Grossman , R L , Kim , Y , Heinold , M C , Hinton , J , Jones , D R , Menzies , A , Stebbings , L , Hess , J M , Rosenberg , M , Dunford , A J , Gupta , M , Imielinski , M , Meyerson , M , Beroukhim , R , Reimand , J , Dhingra , P , Favero , F , Dentro , S C , Wintersinger , J , Rudneva , V , Park , J W , Hong , E P , Heo , S G , Kahles , A , Kjong-Van Lehmann , Soulette , C M , Shiraishi , Y , Liu , F , He , Y , Demircioglu , D , Davidson , N R , Greger , L , Li , S , Liu , D , Stark , S G , Zhang , F , Amin , S B , Bailey , P J , Chateigner , A , Frenkel-Morgenstern , M , Hou , Y , Huska , M R , Kilpinen , H , Lamaze , F C , Li , C , Li , X , Li , X , Liu , X , Marin , M G , Markowski , J , Nandi , T , Ojesina , A , Pan-Hammarstrom , Q , Park , P J , Pedamallu , C S , Su , H , Tan , P , Teh , B T , Wang , J , Xiong , H , Ye , C , Yung , C , Zhang , X , Zheng , L , Zhu , S , Awadalla , P , Creighton , C J , Wu , K , Yang , H , Goke , J , Zhang , Z , Brooks , A N , Martincorena , I , Rubio-Perez , C , Juul , M , Schumacher , S , Shapira , O , Tamborero , D , Mularoni , L , Hornshoj , H , Deu-Pons , J , Muinos , F , Bertl , J , Guo , Q , Bazant , W , Barrera , E , Al-Sedairy , S T , Aretz , A , Bell , C , Betancourt , M , Buchholz , C , Calvo , F , Chomienne , C , Dunn , M , Edmonds , S , Green , E , Gupta , S , Hutter , C M , Jegalian , K , Jones , N , Lu , Y , Nakagama , H , Nettekoven , G , Planko , L , Scott , D , Shibata , T , Shimizu , K , Stratton , M R , Yugawa , T , Tortora , G , VijayRaghavan , K , Zenklusen , J C , Knoppers , B M , Aminou , B , Bartolome , J , Boroevich , K A , Boyce , R , Buchanan , A , Byrne , N J , Chen , Z , Cho , S , Choi , W , Clapham , P , Dow , M T , Dursi , L J , Eils , J , Farcas , C , Fayzullaev , N , Flicek , P , Heath , A P , Hofmann , O , Hong , J H , Hudson , T J , Huebschmann , D , Ivkovic , S , Jeon , S-H , Jiao , W , Kabbe , R , Kerssemakers , J N A , Kim , H , Kim , J , Koscher , M , Koures , A , Kovacevic , M , Lawerenz , C , Liu , J , Mijalkovic , S , Mijalkovic-Lazic , A M , Miyano , S , Nastic , M , Nicholson , J , Ocana , D , Ohi , K , Ohno-Machado , L , Pihl , T D , Prinz , M , Radovic , P , Short , C , Sofia , H J , Spring , J , Struck , A J , Tijanic , N , Vicente , D , Wang , Z , Williams , A , Woo , Y , Wright , A J , Yang , L , Hamilton , M P , Johnson , T A , Kahraman , A , Kellis , M , Polak , P , Sallari , R , Sinnott-Armstrong , N , von Mering , C , Beltran , S , Gerhard , D S , Gut , M , Trotta , J-R , Whalley , J P , Niu , B , Espiritu , S M G , Gao , S , Huang , Y , Lalansingh , C M , Teague , J W , Wendl , M C , Abascal , F , Bader , G D , Bandopadhayay , P , Barenboim , J , Brunak , S , Fita , J C , Chakravarty , D , Chan , C W Y , Choi , J K , Diamanti , K , Fink , J L , Frigola , J , Gambacorti-Passerini , C , Garsed , D W , Haradhvala , N J , Harmanci , A O , Helmy , M , Herrmann , C , Hobolth , A , Hodzic , E , Hong , C , Isaev , K , Izarzugaza , J M G , Johnson , R , Juul , R I , Kim , J , Kim , J K , Komorowski , J , Lanzos , A , Larsson , E , Lee , D , Li , S , Li , X , Lin , Z , Liu , E M , Lochovsky , L , Lou , S , Madsen , T , Marchal , K , Fundichely , A M , McGillivray , P D , Meyerson , W , Paczkowska , M , Park , K , Park , K , Pons , T , Pulido-Tamayo , S , Reyes Salazar , I , Reyna , M A , Rubin , M A , Salichos , L , Sander , C , Schumacher , S E , Shackleton , M , Shen , C , Shrestha , R , Shuai , S , Tsunoda , T , Umer , H M , Uuskula-Reimand , L , Verbeke , L P C , Wadelius , C , Wadi , L , Warrell , J , Wu , G , Yu , J , Zhang , J , Zhang , X , Zhang , Y , Zhao , Z , Zou , L , Lawrence , M S , Raphael , B J , Bailey , P J , Craft , D , Goldman , M J , Aburatani , H , Binder , H , Dinh , H Q , Heath , S C , Hoffmann , S , Imbusch , C D , Kretzmer , H , Laird , P W , Martin-Subero , J , Nagae , G , Shen , H , Wang , Q , Weichenhan , D , Zhou , W , Berman , B P , Brors , B , Plass , C , Akdemir , K C , Bowtell , D D L , Burns , K H , Busanovich , J , Chan , K , Dueso-Barroso , A , Edwards , P A , Etemadmoghadam , D , Haber , J E , Jones , D T W , Ju , Y S , Kazanov , M D , Koh , Y , Kumar , K , Lee , E A , Lee , J J-K , Lynch , A G , Macintyre , G , Markowetz , F , Navarro , F C P , Pearson , J , Rippe , K , Scully , R , Villasante , I , Waddell , N , Yang , L , Yao , X , Yoon , S-S , Zhang , C-Z , Bergstrom , E N , Boot , A , Covington , K , Fujimoto , A , Huang , M N , Islam , S M A , McPherson , J R , Morganella , S , Mustonen , V , Ng , A W T , Prokopec , S D , Vazquez-Garcia , I , Wu , Y , Yousif , F , Yu , W , Rozen , S G , Rudneva , V A , Shringarpure , S S , Turner , D J , Xia , T , Atwal , G , Chang , D K , Cooke , S L , Faltas , B M , Haider , S , Kaiser , V B , Karlic , R , Kato , M , Kubler , K , Margolin , A , Martin , S , Nik-Zainal , S , P'ng , C , Semple , C A , Smith , J , Sun , R X , Thai , K , Wright , D W , Yuan , K , Biankin , A , Garraway , L , Grimmond , S M , Adams , D J , Anur , P , Cao , S , Christie , E L , Cmero , M , Cun , Y , Dawson , K J , Dentro , S C , Deshwar , A G , Donmez , N , Drews , R M , Gerstung , M , Ha , G , Haase , K , Jerman , L , Ji , Y , Jolly , C , Lee , J , Lee-Six , H , Malikic , S , Mitchell , T J , Morris , Q D , Oesper , L , Peifer , M , Peto , M , Rosebrock , D , Rubanova , Y , Salcedo , A , Sengupta , S , Shi , R , Shin , S J , Spiro , O , Vembu , S , Wintersinger , J A , Yang , T-P , Yu , K , Zhu , H , Spellman , P T , Weinstein , J N , Chen , Y , Fujita , M , Han , L , Hasegawa , T , Komura , M , Li , J , Mizuno , S , Shimizu , E , Wang , Y , Xu , Y , Yamaguchi , R , Yang , F , Yang , Y , Yoon , C J , Yuan , Y , Liang , H , Alawi , M , Borozan , I , Brewer , D S , Cooper , C S , Desai , N , Grundhoff , A , Iskar , M , Su , X , Zapatka , M , Lichter , P , Alsop , K , Bruxner , T J C , Christ , A N , Cordner , S M , Cowin , P A , Drapkin , R , Fereday , S , George , J , Hamilton , A , Holmes , O , Hung , J A , Kassahn , K S , Kazakoff , S H , Kennedy , C J , Leonard , C R , Mileshkin , L , Miller , D K , Arnau , G M , Mitchell , C , Newell , F , Nones , K , Patch , A-M , Quinn , M C , Taylor , D F , Thorne , H , Traficante , N , Vedururu , R , Waddell , N M , Waring , P M , Wood , S , Xu , Q , DeFazio , A , Anderson , M J , Antonello , D , Barbour , A P , Bassi , C , Bersani , S , Cataldo , I , Chantrill , L A , Chiew , Y-E , Chou , A , Cingarlini , S , Cloonan , N , Corbo , V , Davi , M V , Duthie , F R , Gill , A J , Graham , J S , Harliwong , I , Jamieson , N B , Johns , A L , Kench , J G , Landoni , L , Lawlor , R T , Mafficini , A , Merrett , N D , Miotto , M , Musgrove , E A , Nagrial , A M , Oien , K A , Pajic , M , Pinese , M , Robertson , A J , Rooman , I , Rusev , B C , Samra , J S , Scardoni , M , Scarlett , C J , Scarpa , A , Sereni , E , Sikora , K O , Simbolo , M , Taschuk , M L , Toon , C W , Vicentini , C , Wu , J , Zeps , N , Behren , A , Burke , H , Cebon , J , Dagg , R A , De Paoli-Iseppi , R , Dutton-Regester , K , Field , M A , Fitzgerald , A , Hersey , P , Jakrot , V , Johansson , P A , Kakavand , H , Kefford , R F , Lau , L M S , Long , G , Pickett , H A , Pritchard , A L , Pupo , G M , Saw , R P M , Schramm , S-J , Shang , C A , Shang , P , Spillane , A J , Stretch , J R , Tembe , V , Thompson , J F , Vilain , R E , Wilmott , J S , Yang , J Y , Hayward , N K , Mann , G J , Scolyer , R A , Bartlett , J , Bavi , P , Chadwick , D E , Chan-Seng-Yue , M , Cleary , S , Connor , A A , Czajka , K , Denroche , R E , Dhani , N C , Eagles , J , Gallinger , S , Grant , R C , Hedley , D , Hollingsworth , M A , Jang , G H , Johns , J , Kalimuthu , S , Liang , S-B , Lungu , I , Luo , X , Mbabaali , F , McPherson , T A , Miller , J K , Moore , M J , Notta , F , Pasternack , D , Petersen , G M , Roehrl , M H A , Sam , M , Selander , I , Serra , S , Shahabi , S , Thayer , S P , Timms , L E , Wilson , G W , Wilson , J M , Wouters , B G , McPherson , J D , Beck , T A , Bhandari , V , Collins , C C , Fleshner , N E , Fox , N S , Fraser , M , Heisler , L E , Lalonde , E , Livingstone , J , Meng , A , Sabelnykova , V Y , Shiah , Y-J , Van Der Kwast , T , Bristow , R G , Ding , S , Fan , D , Li , L , Nie , Y , Xiao , X , Xing , R , Yang , S , Yu , Y , Zhou , Y , Banks , R E , Bourque , G , Brennan , P , Letourneau , L , Riazalhosseini , Y , Scelo , G , Vasudev , N , Viksna , J , Lathrop , M , Tost , J , Ahn , S-M , Aparicio , S , Arnould , L , Aure , M R , Bhosle , S G , Birney , E , Borg , A , Boyault , S , Brinkman , A B , Brock , J E , Broeks , A , Borresen-Dale , A-L , Caldas , C , Chin , S-F , Davies , H , Desmedt , C , Dirix , L , Dronov , S , Ehinger , A , Eyfjord , J E , Fatima , A , Foekens , J A , Futreal , P A , Garred , O , Giri , D D , Glodzik , D , Grabau , D , Hilmarsdottir , H , Hooijer , G K , Jacquemier , J , Jang , S J , Jonasson , J G , Jonkers , J , Kim , H-Y , King , T A , Knappskog , S , Kong , G , Krishnamurthy , S , Lakhani , S R , Langerod , A , Larsimont , D , Lee , H J , Lee , J-Y , Lee , M T M , Lingjaerde , O C , MacGrogan , G , Martens , J W M , O'Meara , S , Pauporte , I , Pinder , S , Pivot , X , Provenzano , E , Purdie , C A , Ramakrishna , M , Ramakrishnan , K , Reis-Filho , J , Richardson , A L , Ringner , M , Rodriguez , J B , Rodriguez-Gonzalez , F G , Romieu , G , Salgado , R , Sauer , T , Shepherd , R , Sieuwerts , A M , Simpson , P T , Smid , M , Sotiriou , C , Span , P N , Stefansson , O A , Stenhouse , A , Stunnenberg , H G , Sweep , F , Tan , B K T , Thomas , G , Thompson , A M , Tommasi , S , Treilleux , I , Tutt , A , Ueno , N T , Van Laere , S , Van den Eynden , G G , Vermeulen , P , Viari , A , Vincent-Salomon , A , Wong , B H , Yates , L , Zou , X , van Deurzen , C H M , van de Vijver , M J , van't Veer , L , Ammerpohl , O , Aukema , S , Bergmann , A K , Bernhart , S H , Borkhardt , A , Borst , C , Burkhardt , B , Claviez , A , Goebler , M E , Haake , A , Haas , S , Hansmann , M , Hoell , J , Hummel , M , Karsch , D , Klapper , W , Kneba , M , Kreuz , M , Kube , D , Kueppers , R , Lenze , D , Loeffler , M , Lopez , C , Mantovani-Loeffler , L , Moeller , P , Ott , G , Radlwimmer , B , Richter , J , Rohde , M , Rosenstiel , P C , Rosenwald , A , Schilhabel , M B , Schreiber , S , Stadler , P F , Staib , P , Stilgenbauer , S , Sungalee , S , Szczepanowski , M , Toprak , U H , Truemper , L H P , Wagener , R , Zenz , T , Hovestadt , V , von Kalle , C , Kool , M , Korshunov , A , Landgraf , P , Lehrach , H , Northcott , P A , Pfister , S M , Reifenberger , G , Warnatz , H-J , Wolf , S , Yaspo , M-L , Assenov , Y , Gerhauser , C , Minner , S , Schlomm , T , Simon , R , Sauter , G , Sueltmann , H , Biswas , N K , Maitra , A , Majumder , P P , Sarin , R , Barbi , S , Bonizzato , G , Cantu , C , Dei Tos , A P , Fassan , M , Grimaldi , S , Luchini , C , Malleo , G , Marchegiani , G , Milella , M , Paiella , S , Pea , A , Pederzoli , P , Ruzzenente , A , Salvia , R , Sperandio , N , Arai , Y , Hama , N , Hiraoka , N , Hosoda , F , Nakamura , H , Ojima , H , Okusaka , T , Totoki , Y , Urushidate , T , Fukayama , M , Ishikawa , S , Katai , H , Katoh , H , Komura , D , Rokutan , H , Saito-Adachi , M , Suzuki , A , Taniguchi , H , Tatsuno , K , Ushiku , T , Yachida , S , Yamamoto , S , Aikata , H , Arihiro , K , Ariizumi , S , Chayama , K , Furuta , M , Gotoh , K , Hayami , S , Hirano , S , Kawakami , Y , Maejima , K , Nakamura , T , Nakano , K , Ohdan , H , Sasaki-Oku , A , Tanaka , H , Ueno , M , Yamamoto , M , Yamaue , H , Choo , S P , Cutcutache , I , Khuntikeo , N , Ong , C K , Pairojkul , C , Popescu , I , Ahn , K S , Aymerich , M , Lopez-Guillermo , A , Lopez-Otin , C , Puente , X S , Campo , E , Amary , F , Baumhoer , D , Behjati , S , Bjerkehagen , B , Futreal , P A , Myklebost , O , Pillay , N , Tarpey , P , Tirabosco , R , Zaikova , O , Flanagan , A M , Boultwood , J , Bowen , D T , Cazzola , M , Green , A R , Hellstrom-Lindberg , E , Malcovati , L , Nangalia , J , Papaemmanuil , E , Vyas , P , Ang , Y , Barr , H , Beardsmore , D , Eldridge , M , Gossage , J , Grehan , N , Hanna , G B , Hayes , S J , Hupp , T R , Khoo , D , Lagergren , J , Lovat , L B , MacRae , S , O'Donovan , M , O'Neill , J R , Parsons , S L , Preston , S R , Puig , S , Roques , T , Sanders , G , Sothi , S , Tavare , S , Tucker , O , Turkington , R , Underwood , T J , Welch , I , Fitzgerald , R C , Berney , D M , De Bono , J S , Cahill , D , Camacho , N , Dennis , N M , Dudderidge , T , Edwards , S E , Fisher , C , Foster , C S , Ghori , M , Gill , P , Gnanapragasam , V J , Gundem , G , Hamdy , F C , Hawkins , S , Hazell , S , Howat , W , Isaacs , W B , Karaszi , K , Kay , J D , Khoo , V , Kote-Jarai , Z , Kremeyer , B , Kumar , P , Lambert , A , Leongamornlert , D A , Livni , N , Lu , Y-J , Luxton , H J , Marsden , L , Massie , C E , Matthews , L , Mayer , E , McDermott , U , Merson , S , Neal , D E , Ng , A , Nicol , D , Ogden , C , Rowe , E W , Shah , N C , Thomas , S , Thompson , A , Verrill , C , Visakorpi , T , Warren , A Y , Whitaker , H C , Zhang , H , van As , N , Eeles , R A , Abeshouse , A , Agrawal , N , Akbani , R , Al Ahmadie , H , Albert , M , Aldape , K , Ally , A , Appelbaum , E L , Armenia , J , Asa , S , Auman , J T , Balasundaram , M , Balu , S , Barnholtz-Sloan , J , Bathe , O F , Baylin , S B , Benz , C , Berchuck , A , Berrios , M , Bigner , D , Birrer , M , Bodenheimer , T , Boice , L , Bootwalla , M S , Bosenberg , M , Bowlby , R , Boyd , J , Broaddus , R R , Brock , M , Brooks , D , Bullman , S , Caesar-Johnson , S J , Carey , T E , Carlsen , R , Cerfolio , R , Chandan , V S , Chen , H-W , Cherniack , A D , Chien , J , Cho , J , Chuah , E , Cibulskis , C , Cope , L , Cordes , M G , Curley , E , Czerniak , B , Danilova , L , Davis , I J , Defreitas , T , Demchok , J A , Dhalla , N , Dhir , R , Doddapaneni , H , El-Naggar , A , Felau , I , Ferguson , M L , Finocchiaro , G , Fong , K M , Frazer , S , Friedman , W , Fronick , C C , Fulton , L A , Gabriel , S B , Gao , J , Gehlenborg , N , Gershenwald , J E , Ghossein , R , Giama , N H , Gibbs , R A , Gomez , C , Govindan , R , Hayes , D N , Hegde , A M , Heiman , D , Heins , Z , Hepperla , A J , Holbrook , A , Holt , R A , Hoyle , A P , Hruban , R H , Hu , J , Huang , M , Huntsman , D , Huse , J , Donahue , C A I , Ittmann , M , Jayaseelan , J C , Jefferys , S R , Jones , C D , Jones , S J M , Juhl , H , Kang , K J , Karlan , B , Kasaian , K , Kebebew , E , Kim , H K , Korchina , V , Kundra , R , Lai , P H , Lander , E , Le , X , Lee , D , Levine , D A , Lewis , L , Ley , T , Li , H I , Lin , P , Linehan , W M , Liu , F F , Lu , Y , Lype , L , Ma , Y , Maglinte , D T , Mardis , E R , Marks , J , Marra , M A , Matthew , T J , Mayo , M , McCune , K , Meier , S R , Meng , S , Mieczkowski , P A , Mikkelsen , T , Miller , C A , Mills , G B , Moore , R A , Morrison , C , Mose , L E , Moser , C D , Mungall , A J , Mungall , K , Mutch , D , Muzny , D M , Myers , J , Newton , Y , Noble , M S , O'Donnell , P , O'Neill , B P , Ochoa , A , Park , J-W , Parker , J S , Pass , H , Pastore , A , Pennell , N A , Perou , C M , Petrelli , N , Potapova , O , Rader , J S , Ramalingam , S , Rathmell , W K , Reuter , V , Reynolds , S M , Ringel , M , Roach , J , Roberts , L R , Robertson , A G , Sadeghi , S , Saller , C , Sanchez-Vega , F , Schadendorf , D , Schein , J E , Schmidt , H K , Schultz , N , Seethala , R , Senbabaoglu , Y , Shelton , T , Shi , Y , Shih , J , Shmulevich , I , Shriver , C , Signoretti , S , Simons , J , Singer , S , Sipahimalani , P , Skelly , T J , McCune , K S , Socci , N D , Soloway , M G , Sood , A K , Tam , A , Tan , D , Tarnuzzer , R , Thiessen , N , Thompson , R H , Thorne , L B , Tsao , M , Umbricht , C , Van Den Berg , D J , Van Meir , E G , Veluvolu , U , Voet , D , Wang , L , Weinberger , P , Weisenberger , D J , Wigle , D , Wilkerson , M D , Wilson , R K , Winterhoff , B , Wiznerowicz , M , Wong , T , Wong , W , Xi , L , Yau , C , Zhang , H , Zhang , H & Zhang , J 2020 , ' Pan-cancer analysis of whole genomes ' , Nature , vol. 578 , no. 7793 , pp. 82-+ . https://doi.org/10.1038/s41586-020-1969-6

Title: Pan-cancer analysis of whole genomes
Author: Campbell, Peter J.; Getz, Gad; Korbel, Jan O.; Stuart, Joshua M.; Jennings, Jennifer L.; Stein, Lincoln D.; Perry, Marc D.; Nahal-Bose, Hardeep K.; Ouellette, B. F. Francis; Li, Constance H.; Rheinbay, Esther; Nielsen, G. Petur; Sgroi, Dennis C.; Wu, Chin-Lee; Faquin, William C.; Deshpande, Vikram; Boutros, Paul C.; Lazar, Alexander J.; Hoadley, Katherine A.; Louis, David N.; Dursi, L. Jonathan; Yung, Christina; Bailey, Matthew H.; Saksena, Gordon; Raine, Keiran M.; Buchhalter, Ivo; Kleinheinz, Kortine; Schlesner, Matthias; Zhang, Junjun; Wang, Wenyi; Wheeler, David A.; Ding, Li; Simpson, Jared T.; O'Connor, Brian D.; Yakneen, Sergei; Ellrott, Kyle; Miyoshi, Naoki; Butler, Adam P.; Royo, Romina; Shorser, Solomon; Vazquez, Miguel; Rausch, Tobias; Tiao, Grace; Waszak, Sebastian M.; Rodriguez-Martin, Bernardo; Shringarpure, Suyash; Wu, Dai-Ying; Demidov, German M.; Delaneau, Olivier; Hayashi, Shuto; Imoto, Seiya; Habermann, Nina; Segre, Ayellet; Garrison, Erik; Cafferkey, Andy; Alvarez, Eva G.; Maria Heredia-Genestar, Jose; Muyas, Francesc; Drechsel, Oliver; Bruzos, Alicia L.; Temes, Javier; Zamora, Jorge; Baez-Ortega, Adrian; Kim, Hyung-Lae; Mashl, R. Jay; Ye, Kai; DiBiase, Anthony; Huang, Kuan-lin; Letunic, Ivica; McLellan, Michael D.; Newhouse, Steven J.; Shmaya, Tal; Kumar, Sushant; Wedge, David C.; Wright, Mark H.; Yellapantula, Venkata D.; Gerstein, Mark; Khurana, Ekta; Marques-Bonet, Tomas; Navarro, Arcadi; Bustamante, Carlos D.; Siebert, Reiner; Nakagawa, Hidewaki; Easton, Douglas F.; Ossowski, Stephan; Tubio, Jose M. C.; De La Vega, Francisco M.; Estivill, Xavier; Yuen, Denis; Mihaiescu, George L.; Omberg, Larsson; Ferretti, Vincent; Sabarinathan, Radhakrishnan; Pich, Oriol; Gonzalez-Perez, Abel; Weiner, Amaro Taylor; Fittall, Matthew W.; Demeulemeester, Jonas; Tarabichi, Maxime; Roberts, Nicola D.; Van Loo, Peter; Cortes-Ciriano, Isidro; Urban, Lara; Park, Peter; Bin Zhu, Lingli; Pitkaenen, Esa; Li, Yilong; Saini, Natalie; Klimczak, Leszek J.; Weischenfeldt, Joachim; Sidiropoulos, Nikos; Alexandrov, Ludmil B.; Rabionet, Raquel; Escaramis, Georgia; Bosio, Mattia; Holik, Aliaksei Z.; Susak, Hana; Prasad, Aparna; Erkek, Serap; Calabrese, Claudia; Raeder, Benjamin; Harrington, Eoghan; Mayes, Simon; Turner, Daniel; Juul, Sissel; Roberts, Steven A.; Song, Lei; Koster, Roelof; Mirabello, Lisa; Hua, Xing; Tanskanen, Tomas J.; Tojo, Marta; Chen, Jieming; Aaltonen, Lauri A.; Ratsch, Gunnar; Schwarz, Roland F.; Butte, Atul J.; Brazma, Alvis; Chanock, Stephen J.; Chatterjee, Nilanjan; Stegle, Oliver; Harismendy, Olivier; Bova, G. Steven; Gordenin, Dmitry A.; Haan, David; Sieverling, Lina; Feuerbach, Lars; Chalmers, Don; Joly, Yann; Knoppers, Bartha M.; Molnar-Gabor, Fruzsina; Phillips, Mark; Thorogood, Adrian; Townend, David; Goldman, Mary; Fonseca, Nuno A.; Xiang, Qian; Craft, Brian; Pineiro-Yanez, Elena; Munoz, Alfonso; Petryszak, Robert; Fullgrabe, Anja; Al-Shahrour, Fatima; Keays, Maria; Haussler, David; Weinstein, John; Huber, Wolfgang; Valencia, Alfonso; Papatheodorou, Irene; Zhu, Jingchun; Fan, Yu; Torrents, David; Bieg, Matthias; Chen, Ken; Chong, Zechen; Cibulskis, Kristian; Eils, Roland; Fulton, Robert S.; Gelpi, Josep L.; Gonzalez, Santiago; Gut, Ivo G.; Hach, Faraz; Heinold, Michael; Hu, Taobo; Huang, Vincent; Hutter, Barbara; Jaeger, Natalie; Jung, Jongsun; Kumar, Yogesh; Lalansingh, Christopher; Leshchiner, Ignaty; Livitz, Dimitri; Ma, Eric Z.; Maruvka, Yosef E.; Milovanovic, Ana; Nielsen, Morten Muhlig; Paramasivam, Nagarajan; Pedersen, Jakob Skou; Puiggros, Montserrat; Sahinalp, S. Cenk; Sarrafi, Iman; Stewart, Chip; Stobbe, Miranda D.; Wala, Jeremiah A.; Wang, Jiayin; Wendl, Michael C.; Werner, Johannes; Wu, Zhenggang; Xue, Hong; Yamaguchi, Takafumi N.; Yellapantula, Venkata; Davis-Dusenbery, Brandi N.; Grossman, Robert L.; Kim, Youngwook; Heinold, Michael C.; Hinton, Jonathan; Jones, David R.; Menzies, Andrew; Stebbings, Lucy; Hess, Julian M.; Rosenberg, Mara; Dunford, Andrew J.; Gupta, Manaswi; Imielinski, Marcin; Meyerson, Matthew; Beroukhim, Rameen; Reimand, Juri; Dhingra, Priyanka; Favero, Francesco; Dentro, Stefan C.; Wintersinger, Jeff; Rudneva, Vasilisa; Park, Ji Wan; Hong, Eun Pyo; Heo, Seong Gu; Kahles, Andre; Kjong-Van Lehmann,; Soulette, Cameron M.; Shiraishi, Yuichi; Liu, Fenglin; He, Yao; Demircioglu, Deniz; Davidson, Natalie R.; Greger, Liliana; Li, Siliang; Liu, Dongbing; Stark, Stefan G.; Zhang, Fan; Amin, Samirkumar B.; Bailey, Peter J.; Chateigner, Aurelien; Frenkel-Morgenstern, Milana; Hou, Yong; Huska, Matthew R.; Kilpinen, Helena; Lamaze, Fabien C.; Li, Chang; Li, Xiaobo; Li, Xinyue; Liu, Xingmin; Marin, Maximillian G.; Markowski, Julia; Nandi, Tannistha; Ojesina, Akinyemi; Pan-Hammarstrom, Qiang; Park, Peter J.; Pedamallu, Chandra Sekhar; Su, Hong; Tan, Patrick; Teh, Bin Tean; Wang, Jian; Xiong, Heng; Ye, Chen; Yung, Christina; Zhang, Xiuqing; Zheng, Liangtao; Zhu, Shida; Awadalla, Philip; Creighton, Chad J.; Wu, Kui; Yang, Huanming; Goke, Jonathan; Zhang, Zemin; Brooks, Angela N.; Martincorena, Inigo; Rubio-Perez, Carlota; Juul, Malene; Schumacher, Steven; Shapira, Ofer; Tamborero, David; Mularoni, Loris; Hornshoj, Henrik; Deu-Pons, Jordi; Muinos, Ferran; Bertl, Johanna; Guo, Qianyun; Bazant, Wojciech; Barrera, Elisabet; Al-Sedairy, Sultan T.; Aretz, Axel; Bell, Cindy; Betancourt, Miguel; Buchholz, Christiane; Calvo, Fabien; Chomienne, Christine; Dunn, Michael; Edmonds, Stuart; Green, Eric; Gupta, Shailja; Hutter, Carolyn M.; Jegalian, Karine; Jones, Nic; Lu, Youyong; Nakagama, Hitoshi; Nettekoven, Gerd; Planko, Laura; Scott, David; Shibata, Tatsuhiro; Shimizu, Kiyo; Stratton, Michael R.; Yugawa, Takashi; Tortora, Giampaolo; VijayRaghavan, K.; Zenklusen, Jean C.; Knoppers, Bartha M.; Aminou, Brice; Bartolome, Javier; Boroevich, Keith A.; Boyce, Rich; Buchanan, Alex; Byrne, Niall J.; Chen, Zhaohong; Cho, Sunghoon; Choi, Wan; Clapham, Peter; Dow, Michelle T.; Dursi, Lewis Jonathan; Eils, Juergen; Farcas, Claudiu; Fayzullaev, Nodirjon; Flicek, Paul; Heath, Allison P.; Hofmann, Oliver; Hong, Jongwhi H.; Hudson, Thomas J.; Huebschmann, Daniel; Ivkovic, Sinisa; Jeon, Seung-Hyup; Jiao, Wei; Kabbe, Rolf; Kerssemakers, Jules N. A.; Kim, Hyunghwan; Kim, Jihoon; Koscher, Michael; Koures, Antonios; Kovacevic, Milena; Lawerenz, Chris; Liu, Jia; Mijalkovic, Sanja; Mijalkovic-Lazic, Ana Mijalkovic; Miyano, Satoru; Nastic, Mia; Nicholson, Jonathan; Ocana, David; Ohi, Kazuhiro; Ohno-Machado, Lucila; Pihl, Todd D.; Prinz, Manuel; Radovic, Petar; Short, Charles; Sofia, Heidi J.; Spring, Jonathan; Struck, Adam J.; Tijanic, Nebojsa; Vicente, David; Wang, Zhining; Williams, Ashley; Woo, Youngchoon; Wright, Adam J.; Yang, Liming; Hamilton, Mark P.; Johnson, Todd A.; Kahraman, Abdullah; Kellis, Manolis; Polak, Paz; Sallari, Richard; Sinnott-Armstrong, Nasa; von Mering, Christian; Beltran, Sergi; Gerhard, Daniela S.; Gut, Marta; Trotta, Jean-Remi; Whalley, Justin P.; Niu, Beifang; Espiritu, Shadrielle M. G.; Gao, Shengjie; Huang, Yi; Lalansingh, Christopher M.; Teague, Jon W.; Wendl, Michael C.; Abascal, Federico; Bader, Gary D.; Bandopadhayay, Pratiti; Barenboim, Jonathan; Brunak, Soren; Fita, Joana Carlevaro; Chakravarty, Dimple; Chan, Calvin Wing Yiu; Choi, Jung Kyoon; Diamanti, Klev; Fink, J. Lynn; Frigola, Joan; Gambacorti-Passerini, Carlo; Garsed, Dale W.; Haradhvala, Nicholas J.; Harmanci, Arif O.; Helmy, Mohamed; Herrmann, Carl; Hobolth, Asger; Hodzic, Ermin; Hong, Chen; Isaev, Keren; Izarzugaza, Jose M. G.; Johnson, Rory; Juul, Randi Istrup; Kim, Jaegil; Kim, Jong K.; Komorowski, Jan; Lanzos, Andres; Larsson, Erik; Lee, Donghoon; Li, Shantao; Li, Xiaotong; Lin, Ziao; Liu, Eric Minwei; Lochovsky, Lucas; Lou, Shaoke; Madsen, Tobias; Marchal, Kathleen; Fundichely, Alexander Martinez; McGillivray, Patrick D.; Meyerson, William; Paczkowska, Marta; Park, Keunchil; Park, Kiejung; Pons, Tirso; Pulido-Tamayo, Sergio; Reyes Salazar, Iker; Reyna, Matthew A.; Rubin, Mark A.; Salichos, Leonidas; Sander, Chris; Schumacher, Steven E.; Shackleton, Mark; Shen, Ciyue; Shrestha, Raunak; Shuai, Shimin; Tsunoda, Tatsuhiko; Umer, Husen M.; Uuskula-Reimand, Liis; Verbeke, Lieven P. C.; Wadelius, Claes; Wadi, Lina; Warrell, Jonathan; Wu, Guanming; Yu, Jun; Zhang, Jing; Zhang, Xuanping; Zhang, Yan; Zhao, Zhongming; Zou, Lihua; Lawrence, Michael S.; Raphael, Benjamin J.; Bailey, Peter J.; Craft, David; Goldman, Mary J.; Aburatani, Hiroyuki; Binder, Hans; Dinh, Huy Q.; Heath, Simon C.; Hoffmann, Steve; Imbusch, Charles David; Kretzmer, Helene; Laird, Peter W.; Martin-Subero, Jose; Nagae, Genta; Shen, Hui; Wang, Qi; Weichenhan, Dieter; Zhou, Wanding; Berman, Benjamin P.; Brors, Benedikt; Plass, Christoph; Akdemir, Kadir C.; Bowtell, David D. L.; Burns, Kathleen H.; Busanovich, John; Chan, Kin; Dueso-Barroso, Ana; Edwards, Paul A.; Etemadmoghadam, Dariush; Haber, James E.; Jones, David T. W.; Ju, Young Seok; Kazanov, Marat D.; Koh, Youngil; Kumar, Kiran; Lee, Eunjung Alice; Lee, Jake June-Koo; Lynch, Andy G.; Macintyre, Geoff; Markowetz, Florian; Navarro, Fabio C. P.; Pearson, John; Rippe, Karsten; Scully, Ralph; Villasante, Izar; Waddell, Nicola; Yang, Lixing; Yao, Xiaotong; Yoon, Sung-Soo; Zhang, Cheng-Zhong; Bergstrom, Erik N.; Boot, Arnoud; Covington, Kyle; Fujimoto, Akihiro; Huang, Mi Ni; Islam, S. M. Ashiqul; McPherson, John R.; Morganella, Sandro; Mustonen, Ville; Ng, Alvin Wei Tian; Prokopec, Stephenie D.; Vazquez-Garcia, Ignacio; Wu, Yang; Yousif, Fouad; Yu, Willie; Rozen, Steven G.; Rudneva, Vasilisa A.; Shringarpure, Suyash S.; Turner, Daniel J.; Xia, Tian; Atwal, Gurnit; Chang, David K.; Cooke, Susanna L.; Faltas, Bishoy M.; Haider, Syed; Kaiser, Vera B.; Karlic, Rosa; Kato, Mamoru; Kubler, Kirsten; Margolin, Adam; Martin, Sancha; Nik-Zainal, Serena; P'ng, Christine; Semple, Colin A.; Smith, Jaclyn; Sun, Ren X.; Thai, Kevin; Wright, Derek W.; Yuan, Ke; Biankin, Andrew; Garraway, Levi; Grimmond, Sean M.; Adams, David J.; Anur, Pavana; Cao, Shaolong; Christie, Elizabeth L.; Cmero, Marek; Cun, Yupeng; Dawson, Kevin J.; Dentro, Stefan C.; Deshwar, Amit G.; Donmez, Nilgun; Drews, Ruben M.; Gerstung, Moritz; Ha, Gavin; Haase, Kerstin; Jerman, Lara; Ji, Yuan; Jolly, Clemency; Lee, Juhee; Lee-Six, Henry; Malikic, Salem; Mitchell, Thomas J.; Morris, Quaid D.; Oesper, Layla; Peifer, Martin; Peto, Myron; Rosebrock, Daniel; Rubanova, Yulia; Salcedo, Adriana; Sengupta, Subhajit; Shi, Ruian; Shin, Seung Jun; Spiro, Oliver; Vembu, Shankar; Wintersinger, Jeffrey A.; Yang, Tsun-Po; Yu, Kaixian; Zhu, Hongtu; Spellman, Paul T.; Weinstein, John N.; Chen, Yiwen; Fujita, Masashi; Han, Leng; Hasegawa, Takanori; Komura, Mitsuhiro; Li, Jun; Mizuno, Shinichi; Shimizu, Eigo; Wang, Yumeng; Xu, Yanxun; Yamaguchi, Rui; Yang, Fan; Yang, Yang; Yoon, Christopher J.; Yuan, Yuan; Liang, Han; Alawi, Malik; Borozan, Ivan; Brewer, Daniel S.; Cooper, Colin S.; Desai, Nikita; Grundhoff, Adam; Iskar, Murat; Su, Xiaoping; Zapatka, Marc; Lichter, Peter; Alsop, Kathryn; Bruxner, Timothy J. C.; Christ, Angelika N.; Cordner, Stephen M.; Cowin, Prue A.; Drapkin, Ronny; Fereday, Sian; George, Joshy; Hamilton, Anne; Holmes, Oliver; Hung, Jillian A.; Kassahn, Karin S.; Kazakoff, Stephen H.; Kennedy, Catherine J.; Leonard, Conrad R.; Mileshkin, Linda; Miller, David K.; Arnau, Gisela Mir; Mitchell, Chris; Newell, Felicity; Nones, Katia; Patch, Ann-Marie; Quinn, Michael C.; Taylor, Darrin F.; Thorne, Heather; Traficante, Nadia; Vedururu, Ravikiran; Waddell, Nick M.; Waring, Paul M.; Wood, Scott; Xu, Qinying; DeFazio, Anna; Anderson, Matthew J.; Antonello, Davide; Barbour, Andrew P.; Bassi, Claudio; Bersani, Samantha; Cataldo, Ivana; Chantrill, Lorraine A.; Chiew, Yoke-Eng; Chou, Angela; Cingarlini, Sara; Cloonan, Nicole; Corbo, Vincenzo; Davi, Maria Vittoria; Duthie, Fraser R.; Gill, Anthony J.; Graham, Janet S.; Harliwong, Ivon; Jamieson, Nigel B.; Johns, Amber L.; Kench, James G.; Landoni, Luca; Lawlor, Rita T.; Mafficini, Andrea; Merrett, Neil D.; Miotto, Marco; Musgrove, Elizabeth A.; Nagrial, Adnan M.; Oien, Karin A.; Pajic, Marina; Pinese, Mark; Robertson, Alan J.; Rooman, Ilse; Rusev, Borislav C.; Samra, Jaswinder S.; Scardoni, Maria; Scarlett, Christopher J.; Scarpa, Aldo; Sereni, Elisabetta; Sikora, Katarzyna O.; Simbolo, Michele; Taschuk, Morgan L.; Toon, Christopher W.; Vicentini, Caterina; Wu, Jianmin; Zeps, Nikolajs; Behren, Andreas; Burke, Hazel; Cebon, Jonathan; Dagg, Rebecca A.; De Paoli-Iseppi, Ricardo; Dutton-Regester, Ken; Field, Matthew A.; Fitzgerald, Anna; Hersey, Peter; Jakrot, Valerie; Johansson, Peter A.; Kakavand, Hojabr; Kefford, Richard F.; Lau, Loretta M. S.; Long, Georgina; Pickett, Hilda A.; Pritchard, Antonia L.; Pupo, Gulietta M.; Saw, Robyn P. M.; Schramm, Sarah-Jane; Shang, Catherine A.; Shang, Ping; Spillane, Andrew J.; Stretch, Jonathan R.; Tembe, Varsha; Thompson, John F.; Vilain, Ricardo E.; Wilmott, James S.; Yang, Jean Y.; Hayward, Nicholas K.; Mann, Graham J.; Scolyer, Richard A.; Bartlett, John; Bavi, Prashant; Chadwick, Dianne E.; Chan-Seng-Yue, Michelle; Cleary, Sean; Connor, Ashton A.; Czajka, Karolina; Denroche, Robert E.; Dhani, Neesha C.; Eagles, Jenna; Gallinger, Steven; Grant, Robert C.; Hedley, David; Hollingsworth, Michael A.; Jang, Gun Ho; Johns, Jeremy; Kalimuthu, Sangeetha; Liang, Sheng-Ben; Lungu, Ilinca; Luo, Xuemei; Mbabaali, Faridah; McPherson, Treasa A.; Miller, Jessica K.; Moore, Malcolm J.; Notta, Faiyaz; Pasternack, Danielle; Petersen, Gloria M.; Roehrl, Michael H. A.; Sam, Michelle; Selander, Iris; Serra, Stefano; Shahabi, Sagedeh; Thayer, Sarah P.; Timms, Lee E.; Wilson, Gavin W.; Wilson, Julie M.; Wouters, Bradly G.; McPherson, John D.; Beck, Timothy A.; Bhandari, Vinayak; Collins, Colin C.; Fleshner, Neil E.; Fox, Natalie S.; Fraser, Michael; Heisler, Lawrence E.; Lalonde, Emilie; Livingstone, Julie; Meng, Alice; Sabelnykova, Veronica Y.; Shiah, Yu-Jia; Van Der Kwast, Theodorus; Bristow, Robert G.; Ding, Shuai; Fan, Daiming; Li, Lin; Nie, Yongzhan; Xiao, Xiao; Xing, Rui; Yang, Shanlin; Yu, Yingyan; Zhou, Yong; Banks, Rosamonde E.; Bourque, Guillaume; Brennan, Paul; Letourneau, Louis; Riazalhosseini, Yasser; Scelo, Ghislaine; Vasudev, Naveen; Viksna, Juris; Lathrop, Mark; Tost, Jorg; Ahn, Sung-Min; Aparicio, Samuel; Arnould, Laurent; Aure, M. R.; Bhosle, Shriram G.; Birney, Ewan; Borg, Ake; Boyault, Sandrine; Brinkman, Arie B.; Brock, Jane E.; Broeks, Annegien; Borresen-Dale, Anne-Lise; Caldas, Carlos; Chin, Suet-Feung; Davies, Helen; Desmedt, Christine; Dirix, Luc; Dronov, Serge; Ehinger, Anna; Eyfjord, Jorunn E.; Fatima, Aquila; Foekens, John A.; Futreal, P. A.; Garred, Oystein; Giri, Dilip D.; Glodzik, Dominik; Grabau, Dorthe; Hilmarsdottir, Holmfridur; Hooijer, Gerrit K.; Jacquemier, Jocelyne; Jang, Se Jin; Jonasson, Jon G.; Jonkers, Jos; Kim, Hyung-Yong; King, Tari A.; Knappskog, Stian; Kong, Gu; Krishnamurthy, Savitri; Lakhani, Sunil R.; Langerod, Anita; Larsimont, Denis; Lee, Hee Jin; Lee, Jeong-Yeon; Lee, Ming Ta Michael; Lingjaerde, Ole Christian; MacGrogan, Gaetan; Martens, John W. M.; O'Meara, Sarah; Pauporte, Iris; Pinder, Sarah; Pivot, Xavier; Provenzano, Elena; Purdie, Colin A.; Ramakrishna, Manasa; Ramakrishnan, Kamna; Reis-Filho, Jorge; Richardson, Andrea L.; Ringner, Markus; Rodriguez, Javier Bartolome; Rodriguez-Gonzalez, F. German; Romieu, Gilles; Salgado, Roberto; Sauer, Torill; Shepherd, Rebecca; Sieuwerts, Anieta M.; Simpson, Peter T.; Smid, Marcel; Sotiriou, Christos; Span, Paul N.; Stefansson, Olafur Andri; Stenhouse, Alasdair; Stunnenberg, Henk G.; Sweep, Fred; Tan, Benita Kiat Tee; Thomas, Gilles; Thompson, Alastair M.; Tommasi, Stefania; Treilleux, Isabelle; Tutt, Andrew; Ueno, Naoto T.; Van Laere, Steven; Van den Eynden, Gert G.; Vermeulen, Peter; Viari, Alain; Vincent-Salomon, Anne; Wong, Bernice H.; Yates, Lucy; Zou, Xueqing; van Deurzen, Carolien H. M.; van de Vijver, Marc J.; van't Veer, Laura; Ammerpohl, Ole; Aukema, Sietse; Bergmann, Anke K.; Bernhart, Stephan H.; Borkhardt, Arndt; Borst, Christoph; Burkhardt, Birgit; Claviez, Alexander; Goebler, Maria Elisabeth; Haake, Andrea; Haas, Siegfried; Hansmann, Martin; Hoell, Jessica; Hummel, Michael; Karsch, Dennis; Klapper, Wolfram; Kneba, Michael; Kreuz, Markus; Kube, Dieter; Kueppers, Ralf; Lenze, Dido; Loeffler, Markus; Lopez, Cristina; Mantovani-Loeffler, Luisa; Moeller, Peter; Ott, German; Radlwimmer, Bernhard; Richter, Julia; Rohde, Marius; Rosenstiel, Philip C.; Rosenwald, Andreas; Schilhabel, Markus B.; Schreiber, Stefan; Stadler, Peter F.; Staib, Peter; Stilgenbauer, Stephan; Sungalee, Stephanie; Szczepanowski, Monika; Toprak, Umut H.; Truemper, Lorenz H. P.; Wagener, Rabea; Zenz, Thorsten; Hovestadt, Volker; von Kalle, Christof; Kool, Marcel; Korshunov, Andrey; Landgraf, Pablo; Lehrach, Hans; Northcott, Paul A.; Pfister, Stefan M.; Reifenberger, Guido; Warnatz, Hans-Joerg; Wolf, Stephan; Yaspo, Marie-Laure; Assenov, Yassen; Gerhauser, Clarissa; Minner, Sarah; Schlomm, Thorsten; Simon, Ronald; Sauter, Guido; Sueltmann, Holger; Biswas, Nidhan K.; Maitra, Arindam; Majumder, Partha P.; Sarin, Rajiv; Barbi, Stefano; Bonizzato, Giada; Cantu, Cinzia; Dei Tos, Angelo P.; Fassan, Matteo; Grimaldi, Sonia; Luchini, Claudio; Malleo, Giuseppe; Marchegiani, Giovanni; Milella, Michele; Paiella, Salvatore; Pea, Antonio; Pederzoli, Paolo; Ruzzenente, Andrea; Salvia, Roberto; Sperandio, Nicola; Arai, Yasuhito; Hama, Natsuko; Hiraoka, Nobuyoshi; Hosoda, Fumie; Nakamura, Hiromi; Ojima, Hidenori; Okusaka, Takuji; Totoki, Yasushi; Urushidate, Tomoko; Fukayama, Masashi; Ishikawa, Shumpei; Katai, Hitoshi; Katoh, Hiroto; Komura, Daisuke; Rokutan, Hirofumi; Saito-Adachi, Mihoko; Suzuki, Akihiro; Taniguchi, Hirokazu; Tatsuno, Kenji; Ushiku, Tetsuo; Yachida, Shinichi; Yamamoto, Shogo; Aikata, Hiroshi; Arihiro, Koji; Ariizumi, Shun-ichi; Chayama, Kazuaki; Furuta, Mayuko; Gotoh, Kunihito; Hayami, Shinya; Hirano, Satoshi; Kawakami, Yoshiiku; Maejima, Kazuhiro; Nakamura, Toru; Nakano, Kaoru; Ohdan, Hideki; Sasaki-Oku, Aya; Tanaka, Hiroko; Ueno, Masaki; Yamamoto, Masakazu; Yamaue, Hiroki; Choo, Su Pin; Cutcutache, Ioana; Khuntikeo, Narong; Ong, Choon Kiat; Pairojkul, Chawalit; Popescu, Irinel; Ahn, Keun Soo; Aymerich, Marta; Lopez-Guillermo, Armando; Lopez-Otin, Carlos; Puente, Xose S.; Campo, Elias; Amary, Fernanda; Baumhoer, Daniel; Behjati, Sam; Bjerkehagen, Bodil; Futreal, P. A.; Myklebost, Ola; Pillay, Nischalan; Tarpey, Patrick; Tirabosco, Roberto; Zaikova, Olga; Flanagan, Adrienne M.; Boultwood, Jacqueline; Bowen, David T.; Cazzola, Mario; Green, Anthony R.; Hellstrom-Lindberg, Eva; Malcovati, Luca; Nangalia, Jyoti; Papaemmanuil, Elli; Vyas, Paresh; Ang, Yeng; Barr, Hugh; Beardsmore, Duncan; Eldridge, Matthew; Gossage, James; Grehan, Nicola; Hanna, George B.; Hayes, Stephen J.; Hupp, Ted R.; Khoo, David; Lagergren, Jesper; Lovat, Laurence B.; MacRae, Shona; O'Donovan, Maria; O'Neill, J. Robert; Parsons, Simon L.; Preston, Shaun R.; Puig, Sonia; Roques, Tom; Sanders, Grant; Sothi, Sharmila; Tavare, Simon; Tucker, Olga; Turkington, Richard; Underwood, Timothy J.; Welch, Ian; Fitzgerald, Rebecca C.; Berney, Daniel M.; De Bono, Johann S.; Cahill, Declan; Camacho, Niedzica; Dennis, Nening M.; Dudderidge, Tim; Edwards, Sandra E.; Fisher, Cyril; Foster, Christopher S.; Ghori, Mohammed; Gill, Pelvender; Gnanapragasam, Vincent J.; Gundem, Gunes; Hamdy, Freddie C.; Hawkins, Steve; Hazell, Steven; Howat, William; Isaacs, William B.; Karaszi, Katalin; Kay, Jonathan D.; Khoo, Vincent; Kote-Jarai, Zsofia; Kremeyer, Barbara; Kumar, Pardeep; Lambert, Adam; Leongamornlert, Daniel A.; Livni, Naomi; Lu, Yong-Jie; Luxton, Hayley J.; Marsden, Luke; Massie, Charlie E.; Matthews, Lucy; Mayer, Erik; McDermott, Ultan; Merson, Sue; Neal, David E.; Ng, Anthony; Nicol, David; Ogden, Christopher; Rowe, Edward W.; Shah, Nimish C.; Thomas, Sarah; Thompson, Alan; Verrill, Clare; Visakorpi, Tapio; Warren, Anne Y.; Whitaker, Hayley C.; Zhang, Hongwei; van As, Nicholas; Eeles, Rosalind A.; Abeshouse, Adam; Agrawal, Nishant; Akbani, Rehan; Al Ahmadie, Hikmat; Albert, Monique; Aldape, Kenneth; Ally, Adrian; Appelbaum, Elizabeth L.; Armenia, Joshua; Asa, Sylvia; Auman, J. Todd; Balasundaram, Miruna; Balu, Saianand; Barnholtz-Sloan, Jill; Bathe, Oliver F.; Baylin, Stephen B.; Benz, Christopher; Berchuck, Andrew; Berrios, Mario; Bigner, Darell; Birrer, Michael; Bodenheimer, Tom; Boice, Lori; Bootwalla, Moiz S.; Bosenberg, Marcus; Bowlby, Reanne; Boyd, Jeffrey; Broaddus, Russell R.; Brock, Malcolm; Brooks, Denise; Bullman, Susan; Caesar-Johnson, Samantha J.; Carey, Thomas E.; Carlsen, Rebecca; Cerfolio, Robert; Chandan, Vishal S.; Chen, Hsiao-Wei; Cherniack, Andrew D.; Chien, Jeremy; Cho, Juok; Chuah, Eric; Cibulskis, Carrie; Cope, Leslie; Cordes, Matthew G.; Curley, Erin; Czerniak, Bogdan; Danilova, Ludmila; Davis, Ian J.; Defreitas, Timothy; Demchok, John A.; Dhalla, Noreen; Dhir, Rajiv; Doddapaneni, HarshaVardhan; El-Naggar, Adel; Felau, Ina; Ferguson, Martin L.; Finocchiaro, Gaetano; Fong, Kwun M.; Frazer, Scott; Friedman, William; Fronick, Catrina C.; Fulton, Lucinda A.; Gabriel, Stacey B.; Gao, Jianjiong; Gehlenborg, Nils; Gershenwald, Jeffrey E.; Ghossein, Ronald; Giama, Nasra H.; Gibbs, Richard A.; Gomez, Carmen; Govindan, Ramaswamy; Hayes, D. 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Contributor: University of Helsinki, Faculty of Medicine
University of Helsinki, Lauri Antti Aaltonen / Principal Investigator
University of Helsinki, Helsinki Institute of Life Science HiLIFE
University of Helsinki, Organismal and Evolutionary Biology Research Programme
University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
University of Helsinki, Genome-Scale Biology (GSB) Research Program
University of Helsinki, Department of Physics
Date: 2020-02-06
Language: eng
Number of pages: 50
Belongs to series: Nature
ISSN: 0028-0836
URI: http://hdl.handle.net/10138/315934
Abstract: Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).
Subject: TERT PROMOTER MUTATIONS
SOMATIC MUTATIONS
COMPREHENSIVE CHARACTERIZATION
SYSTEMATIC ANALYSIS
DNA-DAMAGE
LANDSCAPE
SIGNATURES
REARRANGEMENTS
EVOLUTION
PATTERNS
3111 Biomedicine
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