Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis

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http://hdl.handle.net/10138/316035

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Barreto , G , Manninen , M & Eklund , K K 2020 , ' Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis ' , Biology , vol. 9 , no. 4 , 65 . https://doi.org/10.3390/biology9040065

Title: Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis
Author: Barreto, Goncalo; Manninen, Mikko; Eklund, Kari K.
Contributor organization: Reumatologian yksikkö
University of Helsinki
Helsinki University Hospital Area
HUS Inflammation Center
TRIMM - Translational Immunology Research Program
Research Programs Unit
Department of Medicine
Date: 2020-04
Language: eng
Number of pages: 15
Belongs to series: Biology
ISSN: 2079-7737
DOI: https://doi.org/10.3390/biology9040065
URI: http://hdl.handle.net/10138/316035
Abstract: Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In particular, chondrocyte-mediated inflammatory responses triggered by the activation of innate immune receptors by alarmins (also known as danger signals) are thought to be involved. Thus, toll-like receptors (TLRs) and their signaling pathways are of particular interest. Recent reports suggest that among the TLR-induced innate immune responses, apoptosis is one of the critical events. Apoptosis is of particular importance, given that chondrocyte death is a dominant feature in OA. This review focuses on the role of TLR signaling in chondrocytes and the role of TLR activation in chondrocyte apoptosis. The functional relevance of TLR and TLR-triggered apoptosis in OA are discussed as well as their relevance as candidates for novel disease-modifying OA drugs (DMOADs).
Subject: ACTIVATION
CELL-DEATH
EXPRESSION
FIBRONECTIN FRAGMENTS
HUMAN ARTICULAR-CARTILAGE
KNEE OSTEOARTHRITIS
NITRIC-OXIDE
PROTEOGLYCANS DECORIN
RHEUMATOID-ARTHRITIS
SIGNALING PATHWAY
apoptosis
cartilage
chondrocytes
innate immunity
osteoarthritis
toll-like receptors
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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