Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis

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dc.contributor.author Barreto, Goncalo
dc.contributor.author Manninen, Mikko
dc.contributor.author Eklund, Kari K.
dc.date.accessioned 2020-06-11T05:33:01Z
dc.date.available 2020-06-11T05:33:01Z
dc.date.issued 2020-04
dc.identifier.citation Barreto , G , Manninen , M & Eklund , K K 2020 , ' Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis ' , Biology , vol. 9 , no. 4 , 65 . https://doi.org/10.3390/biology9040065
dc.identifier.other PURE: 137331487
dc.identifier.other PURE UUID: bf0fb212-d692-487f-aa6c-27b1405d51af
dc.identifier.other WOS: 000533889200024
dc.identifier.other ORCID: /0000-0003-4444-9208/work/75466113
dc.identifier.uri http://hdl.handle.net/10138/316035
dc.description.abstract Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In particular, chondrocyte-mediated inflammatory responses triggered by the activation of innate immune receptors by alarmins (also known as danger signals) are thought to be involved. Thus, toll-like receptors (TLRs) and their signaling pathways are of particular interest. Recent reports suggest that among the TLR-induced innate immune responses, apoptosis is one of the critical events. Apoptosis is of particular importance, given that chondrocyte death is a dominant feature in OA. This review focuses on the role of TLR signaling in chondrocytes and the role of TLR activation in chondrocyte apoptosis. The functional relevance of TLR and TLR-triggered apoptosis in OA are discussed as well as their relevance as candidates for novel disease-modifying OA drugs (DMOADs). en
dc.format.extent 15
dc.language.iso eng
dc.relation.ispartof Biology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ACTIVATION
dc.subject CELL-DEATH
dc.subject EXPRESSION
dc.subject FIBRONECTIN FRAGMENTS
dc.subject HUMAN ARTICULAR-CARTILAGE
dc.subject KNEE OSTEOARTHRITIS
dc.subject NITRIC-OXIDE
dc.subject PROTEOGLYCANS DECORIN
dc.subject RHEUMATOID-ARTHRITIS
dc.subject SIGNALING PATHWAY
dc.subject apoptosis
dc.subject cartilage
dc.subject chondrocytes
dc.subject innate immunity
dc.subject osteoarthritis
dc.subject toll-like receptors
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3111 Biomedicine
dc.title Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis en
dc.type Review Article
dc.contributor.organization Reumatologian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Inflammation Center
dc.contributor.organization TRIMM - Translational Immunology Research Program
dc.contributor.organization Research Programs Unit
dc.contributor.organization Department of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/biology9040065
dc.relation.issn 2079-7737
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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