Andersen , P I , Ianevski , A , Lysvand , H , Oksenych , V , Bjørås , M , Telling , K , Lutsar , I , Dampis , U , Irie , Y , Tenson , T , Kantele , A & Kainov , D 2020 , ' Discovery and development of safe-in-man broad-spectrum antiviral agents ' , International Journal of Infectious Diseases , vol. 93 , pp. 268-276 . https://doi.org/10.1016/j.ijid.2020.02.018
Title: | Discovery and development of safe-in-man broad-spectrum antiviral agents |
Author: | Andersen, Petter I.; Ianevski, Aleksandr; Lysvand, Hilde; Oksenych, Valentyn; Bjørås, Magnar; Telling, Kaidi; Lutsar, Irja; Dampis, Uga; Irie, Yasuhiko; Tenson, Tanel; Kantele, Anu; Kainov, Denis |
Contributor organization: | Department of Medicine HUS Inflammation Center Institute for Molecular Medicine Finland |
Date: | 2020-04 |
Language: | eng |
Number of pages: | 9 |
Belongs to series: | International Journal of Infectious Diseases |
ISSN: | 1201-9712 |
DOI: | https://doi.org/10.1016/j.ijid.2020.02.018 |
URI: | http://hdl.handle.net/10138/316038 |
Abstract: | Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
Subject: |
317 Pharmacy
Virus Antiviral drug Drug discovery and development Broad-spectrum antiviral agents BSAAs ZIKA VIRUS-INFECTION ANIMAL-MODELS ROTAVIRUS INFECTION SYSTEMATIC ANALYSIS GLOBAL BURDEN 195 COUNTRIES REPLICATION INHIBITION DISEASES DRUGS 3121 General medicine, internal medicine and other clinical medicine |
Peer reviewed: | No |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
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