Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases

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dc.contributor.author Nyberg, Solja T.
dc.contributor.author Singh-Manoux, Archana
dc.contributor.author Pentti, Jaana
dc.contributor.author Madsen, Ida E. H.
dc.contributor.author Sabia, Severine
dc.contributor.author Alfredsson, Lars
dc.contributor.author Bjorner, Jakob B.
dc.contributor.author Borritz, Marianne
dc.contributor.author Burr, Hermann
dc.contributor.author Goldberg, Marcel
dc.contributor.author Heikkila, Katriina
dc.contributor.author Jokela, Markus
dc.contributor.author Knutsson, Anders
dc.contributor.author Lallukka, Tea
dc.contributor.author Lindbohm, Joni
dc.contributor.author Nielsen, Martin L.
dc.contributor.author Nordin, Maria
dc.contributor.author Oksanen, Tuula
dc.contributor.author Pejtersen, Jan H.
dc.contributor.author Rahkonen, Ossi
dc.contributor.author Rugulies, Reiner
dc.contributor.author Shipley, Martin J.
dc.contributor.author Sipila, Pyry N.
dc.contributor.author Stenholm, Sari
dc.contributor.author Suominen, Sakari
dc.contributor.author Vahtera, Jussi
dc.contributor.author Virtanen, Marianna
dc.contributor.author Westerlund, Hugo
dc.contributor.author Zins, Marie
dc.contributor.author Hamer, Mark
dc.contributor.author Batty, G. David
dc.contributor.author Kivimäki, Mika
dc.date.accessioned 2020-06-12T10:39:01Z
dc.date.available 2020-06-12T10:39:01Z
dc.date.issued 2020-05
dc.identifier.citation Nyberg , S T , Singh-Manoux , A , Pentti , J , Madsen , I E H , Sabia , S , Alfredsson , L , Bjorner , J B , Borritz , M , Burr , H , Goldberg , M , Heikkila , K , Jokela , M , Knutsson , A , Lallukka , T , Lindbohm , J , Nielsen , M L , Nordin , M , Oksanen , T , Pejtersen , J H , Rahkonen , O , Rugulies , R , Shipley , M J , Sipila , P N , Stenholm , S , Suominen , S , Vahtera , J , Virtanen , M , Westerlund , H , Zins , M , Hamer , M , Batty , G D & Kivimäki , M 2020 , ' Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases ' , JAMA internal medicine , vol. 180 , no. 5 , pp. 760-768 . https://doi.org/10.1001/jamainternmed.2020.0618
dc.identifier.other PURE: 138700860
dc.identifier.other PURE UUID: ca14018d-d460-4a33-9596-b3da656f8c73
dc.identifier.other WOS: 000534043600025
dc.identifier.other ORCID: /0000-0003-0117-0012/work/75562277
dc.identifier.other ORCID: /0000-0002-7202-3274/work/75562451
dc.identifier.other ORCID: /0000-0002-9820-2692/work/75564006
dc.identifier.uri http://hdl.handle.net/10138/316124
dc.description.abstract This cohort study examines disease-free life-years in participants with varying combinations of lifestyle risk factors. Question Are different combinations of lifestyle factors associated with years lived without chronic diseases? Findings In a multicohort study of 116 & x202f;043 participants, a statistically significant association between overall healthy lifestyle score and an increased number of disease-free life-years was noted. Of 16 different lifestyle profiles studied, the 4 that were associated with the greatest disease-free life years included body mass index lower than 25 and at least 2 of 3 factors: never smoking, physical activity, and moderate alcohol consumption. Meaning Various healthy lifestyle profiles appear to be associated with extended gains in life lived without type 2 diabetes, cardiovascular and respiratory diseases, and cancer. Importance It is well established that selected lifestyle factors are individually associated with lower risk of chronic diseases, but how combinations of these factors are associated with disease-free life-years is unknown. Objective To estimate the association between healthy lifestyle and the number of disease-free life-years. Design, Setting, and Participants A prospective multicohort study, including 12 European studies as part of the Individual-Participant-Data Meta-analysis in Working Populations Consortium, was performed. Participants included 116 & x202f;043 people free of major noncommunicable disease at baseline from August 7, 1991, to May 31, 2006. Data analysis was conducted from May 22, 2018, to January 21, 2020. Exposures Four baseline lifestyle factors (smoking, body mass index, physical activity, and alcohol consumption) were each allocated a score based on risk status: optimal (2 points), intermediate (1 point), or poor (0 points) resulting in an aggregated lifestyle score ranging from 0 (worst) to 8 (best). Sixteen lifestyle profiles were constructed from combinations of these risk factors. Main Outcomes and Measures The number of years between ages 40 and 75 years without chronic disease, including type 2 diabetes, coronary heart disease, stroke, cancer, asthma, and chronic obstructive pulmonary disease. Results Of the 116 & x202f;043 people included in the analysis, the mean (SD) age was 43.7 (10.1) years and 70 & x202f;911 were women (61.1%). During 1.45 million person-years at risk (mean follow-up, 12.5 years; range, 4.9-18.6 years), 17 & x202f;383 participants developed at least 1 chronic disease. There was a linear association between overall healthy lifestyle score and the number of disease-free years, such that a 1-point improvement in the score was associated with an increase of 0.96 (95% CI, 0.83-1.08) disease-free years in men and 0.89 (95% CI, 0.75-1.02) years in women. Comparing the best lifestyle score with the worst lifestyle score was associated with 9.9 (95% CI 6.7-13.1) additional years without chronic diseases in men and 9.4 (95% CI 5.4-13.3) additional years in women (P <.001 for dose-response). All of the 4 lifestyle profiles that were associated with the highest number of disease-free years included a body-mass index less than 25 (calculated as weight in kilograms divided by height in meters squared) and at least 2 of the following factors: never smoking, physical activity, and moderate alcohol consumption. Participants with 1 of these lifestyle profiles reached age 70.3 (95% CI, 69.9-70.8) to 71.4 (95% CI, 70.9-72.0) years disease free depending on the profile and sex. Conclusions and Relevance In this multicohort analysis, various healthy lifestyle profiles appeared to be associated with gains in life-years without major chronic diseases. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof JAMA internal medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject INDIVIDUAL-PARTICIPANT METAANALYSIS
dc.subject JOB STRAIN
dc.subject PHYSICAL INACTIVITY
dc.subject CARDIOVASCULAR RISK
dc.subject MODELS
dc.subject MEN
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases en
dc.type Article
dc.contributor.organization Department of Public Health
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Department of Social Research (2010-2017)
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1001/jamainternmed.2020.0618
dc.relation.issn 2168-6106
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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