Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

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Galluzzi , L , Vitale , I , Warren , S , Adjemian , S , Agostinis , P , Martinez , A B , Chan , T A , Coukos , G , Demaria , S , Deutsch , E , Draganov , D , Edelson , R L , Formenti , S C , Fucikova , J , Gabriele , L , Gaipl , U S , Gameiro , S R , Garg , A D , Golden , E , Han , J , Harrington , K J , Hemminki , A , Hodge , J W , Hossain , D M S , Illidge , T , Karin , M , Kaufman , H L , Kepp , O , Kroemer , G , Lasarte , J J , Loi , S , Lotze , M T , Manic , G , Merghoub , T , Melcher , A A , Mossman , K L , Prosper , F , Rekdal , Ø , Rescigno , M , Riganti , C , Sistigu , A , Smyth , M J , Spisek , R , Stagg , J , Strauss , B E , Tang , D , Tatsuno , K , van Gool , S W , Vandenabeele , P , Yamazaki , T , Zamarin , D , Zitvogel , L , Cesano , A & Marincola , F M 2020 , ' Consensus guidelines for the definition, detection and interpretation of immunogenic cell death ' , Journal for Immunotherapy of Cancer , vol. 8 , no. 1 , 000337 . https://doi.org/10.1136/jitc-2019-000337

Title: Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Author: Galluzzi, Lorenzo; Vitale, Ilio; Warren, Sarah; Adjemian, Sandy; Agostinis, Patrizia; Martinez, Aitziber Buqué; Chan, Timothy A; Coukos, George; Demaria, Sandra; Deutsch, Eric; Draganov, Dobrin; Edelson, Richard L; Formenti, Silvia C; Fucikova, Jitka; Gabriele, Lucia; Gaipl, Udo S; Gameiro, Sofia R; Garg, Abhishek D; Golden, Encouse; Han, Jian; Harrington, Kevin J; Hemminki, Akseli; Hodge, James W; Hossain, Dewan Md Sakib; Illidge, Tim; Karin, Michael; Kaufman, Howard L; Kepp, Oliver; Kroemer, Guido; Lasarte, Juan Jose; Loi, Sherene; Lotze, Michael T; Manic, Gwenola; Merghoub, Taha; Melcher, Alan A; Mossman, Karen L; Prosper, Felipe; Rekdal, Øystein; Rescigno, Maria; Riganti, Chiara; Sistigu, Antonella; Smyth, Mark J; Spisek, Radek; Stagg, John; Strauss, Bryan E; Tang, Daolin; Tatsuno, Kazuki; van Gool, Stefaan W; Vandenabeele, Peter; Yamazaki, Takahiro; Zamarin, Dmitriy; Zitvogel, Laurence; Cesano, Alessandra; Marincola, Francesco M
Contributor: University of Helsinki, Department of Oncology
Date: 2020-03-09
Language: eng
Number of pages: 21
Belongs to series: Journal for Immunotherapy of Cancer
ISSN: 2051-1426
URI: http://hdl.handle.net/10138/316144
Abstract: Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
Subject: 3111 Biomedicine
oncology
immunology
molecular biology
PATTERN-RECOGNITION RECEPTORS
IMMUNE CHECKPOINT BLOCKADE
NOD-LIKE RECEPTORS
NF-KAPPA-B
CALRETICULIN EXPOSURE
CANCER-CELLS
ANTITUMOR IMMUNITY
APOPTOTIC CELLS
ANTICANCER CHEMOTHERAPY
ANTIGEN PRESENTATION
3122 Cancers
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