Cancer Risks Associated With Germline PALB2 Pathogenic Variants : An International Study of 524 Families

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Yang , X , Leslie , G , Doroszuk , A , Aittomäki , K , Blomqvist , C , Heikkinen , T , Nevanlinna , H & Tischkowitz , M 2020 , ' Cancer Risks Associated With Germline PALB2 Pathogenic Variants : An International Study of 524 Families ' , Journal of Clinical Oncology , vol. 38 , no. 7 , pp. 674-+ . https://doi.org/10.1200/JCO.19.01907

Title: Cancer Risks Associated With Germline PALB2 Pathogenic Variants : An International Study of 524 Families
Author: Yang, Xin; Leslie, Goska; Doroszuk, Alicja; Aittomäki, Kristiina; Blomqvist, Carl; Heikkinen, Tuomas; Nevanlinna, Heli; Tischkowitz, Marc
Contributor: University of Helsinki, Medicum
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, Medicum
University of Helsinki, HUS Gynecology and Obstetrics
Date: 2020-03-01
Language: eng
Number of pages: 14
Belongs to series: Journal of Clinical Oncology
ISSN: 0732-183X
URI: http://hdl.handle.net/10138/316171
Abstract: PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis was used to estimate relative risks (RRs; relative to country-specific population incidences) and absolute risks of cancers. The models allowed for residual familial aggregation of breast and ovarian cancer and were adjusted for the family-specific ascertainment schemes. RESULTS We found associations between PALB2 PVs and risk of female breast cancer (RR, 7.18; 95% CI, 5.82 to 8.85; P = 6.5 x 10(-76)), ovarian cancer (RR, 2.91; 95% CI, 1.40 to 6.04; P = 4.1 x 10(-3)), pancreatic cancer (RR, 2.37; 95% CI, 1.24 to 4.50; P = 8.7 x 10(-3)), and male breast cancer (RR, 7.34; 95% CI, 1.28 to 42.18; P = 2.6 x 10(-2)). There was no evidence for increased risks of prostate or colorectal cancer. The breast cancer RRs declined with age (P for trend = 2.0 x 10(-3)). After adjusting for family ascertainment, breast cancer risk estimates on the basis of multiple case families were similar to the estimates from families ascertained through population-based studies (P for difference = .41). On the basis of the combined data, the estimated risks to age 80 years were 53% (95% CI, 44% to 63%) for female breast cancer, 5% (95% CI, 2% to 10%) for ovarian cancer, 2%-3% (95% CI females, 1% to 4%; 95% CI males, 2% to 5%) for pancreatic cancer, and 1% (95% CI, 0.2% to 5%) for male breast cancer. CONCLUSION These results confirm PALB2 as a major breast cancer susceptibility gene and establish substantial associations between germline PALB2 PVs and ovarian, pancreatic, and male breast cancers. These findings will facilitate incorporation of PALB2 into risk prediction models and optimize the clinical cancer risk management of PALB2 PV carriers. (C) 2019 by American Society of Clinical Oncology
Subject: 3122 Cancers
BRCA2-INTERACTING PROTEIN PALB2
ASCERTAINMENT SAMPLING PROBLEM
SUSCEPTIBILITY GENE-MUTATIONS
BREAST-CANCER
PANCREATIC-CANCER
BRCA2
OVARIAN
PENETRANCE
RESOLUTION
HISTORY
BRCA2-INTERACTING PROTEIN PALB2
ASCERTAINMENT SAMPLING PROBLEM
SUSCEPTIBILITY GENE-MUTATIONS
BREAST-CANCER
PANCREATIC-CANCER
BRCA2
OVARIAN
PENETRANCE
RESOLUTION
HISTORY
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