Pregnancy outcomes according to the definition of gestational diabetes

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Koivunen , S , Viljakainen , M , Männistö , T , Gissler , M , Pouta , A , Kaaja , R , Eriksson , J , Laivuori , H , Kajantie , E & Vääräsmäki , M 2020 , ' Pregnancy outcomes according to the definition of gestational diabetes ' , PLoS One , vol. 15 , no. 3 , 0229496 .

Title: Pregnancy outcomes according to the definition of gestational diabetes
Author: Koivunen, Sanna; Viljakainen, Matti; Männistö, Tuija; Gissler, Mika; Pouta, Anneli; Kaaja, Risto; Eriksson, Johan; Laivuori, Hannele; Kajantie, Eero; Vääräsmäki, Marja
Contributor organization: Clinicum
Research Programs Unit
Department of General Practice and Primary Health Care
University of Helsinki
Helsinki University Hospital Area
HUS Gynecology and Obstetrics
Genomics of Neurological and Neuropsychiatric Disorders
Institute for Molecular Medicine Finland
Pregnancy and Genes
Department of Medical and Clinical Genetics
Helsinki Institute of Life Science HiLIFE
HUS Children and Adolescents
Lastentautien yksikkö
Children's Hospital
Date: 2020-03-05
Language: eng
Number of pages: 12
Belongs to series: PLoS One
ISSN: 1932-6203
Abstract: Objective To assess the frequency and perinatal outcomes of gestational diabetes mellitus (GDM) defined by the criteria according to the International Association of Diabetes in Pregnancy Study Group (IADPSG) and the National Institute for Health and Care Excellence (NICE) diagnostic criteria for GDM. Design A retrospective cohort study. Setting Six secondary and tertiary delivery hospitals in Finland in 2009. Population Pregnant women (N = 4,033) and their offspring. Methods We used data on comprehensive screening of pregnant women with a 2-h 75-g oral glucose tolerance test (OGTT), performed between gestational weeks 24 and 40. OGTT glucose concentrations were used to identify women who fulfilled IADPSG and NICE criteria. While cut-offs according to Finnish national criteria partly overlapped with both criteria, a subgroup of IADPSG- or NICE-positive GDM women remained undiagnosed by Finnish criteria and hence non-treated. They were analysed as subgroups and compared to controls who were negative with all cut-offs. Main outcome measures GDM prevalence, birth weight SD score (BWSDS), large for gestational age (LGA) and caesarean section (CS) rates. Results Among the 4,033 women screened for GDM, 1,249 (31.0%) and 529 (13.1%) had GDM according to the IADPSG and NICE criteria, respectively. The LGA rate was similar in both groups. Regardless of the diagnostic criteria, women with GDM had a higher risk of induced delivery and CSs than controls. In IADPSG-positive non-treated women, offspring’s BWSDS and CS rate were higher than in controls. Conclusions GDM prevalence was 2.4-fold higher according to the IADPSG compared with the NICE criteria but the LGA rate did not differ. BWSDS and CS rate were increased already with mild untreated hyperglycaemia.
Subject: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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