First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers

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http://hdl.handle.net/10138/316191

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Viitasalo , L , Iltanen , S , Huhtala , H , Saavalainen , P , Kaukinen , K , Lindfors , K & Kurppa , K 2020 , ' First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers ' , Nutrients , vol. 12 , no. 4 , 1073 . https://doi.org/10.3390/nu12041073

Title: First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers
Author: Viitasalo, Liisa; Iltanen, Sari; Huhtala, Heini; Saavalainen, Päivi; Kaukinen, Katri; Lindfors, Katri; Kurppa, Kalle
Contributor: University of Helsinki, HUSLAB
University of Helsinki, Immunomics
Date: 2020-04
Language: eng
Number of pages: 10
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/316191
Abstract: Risk of celiac disease (CD) is increased in relatives of CD patients due to genetic and possible environmental factors. We recently reported increased seropositivity to anti-Saccharomyces cerevisiae (ASCA), Pseudomonas fluorescens-associated sequence (anti-I2) and Bacteroides caccae TonB-linked outer membrane protein (anti-OmpW) antibodies in CD. We hypothesized these markers also to be overrepresented in relatives. Seropositivity and levels of ASCA, anti-I2 and anti-OmpW were compared between 463 first-degree relatives, 58 untreated and 55 treated CD patients, and 80 controls. CD-associated human leukocyte antigen (HLA)-haplotypes and transglutaminase (tTGab) and endomysium (EmA) antibodies were determined. One or more of the microbial antibodies was present in 75% of relatives, 97% of untreated and 87% of treated CD patients and 44% of the controls. The relatives had higher median ASCA IgA (9.13 vs. 4.50 U/mL, p <0.001), ASCA IgG (8.91 vs. 5.75 U/mL, p <0.001) and anti-I2 (absorbance 0.74 vs. 0.32, p <0.001) levels than controls. There was a weak, positive correlation between tTGab and ASCA (r = 0.31, p <0.001). Seropositivity was not significantly associated with HLA. To conclude, seropositivity to microbial markers was more common and ASCA and anti-I2 levels higher in relatives of CD patients than controls. These findings were not associated with HLA, suggesting the role of other genetic and environmental factors.
Subject: celiac disease
relatives
microbiota
Saccharomyces cerevisiae
Pseudomonas fluorescens
Bacteroides caccae
ANTI-SACCHAROMYCES-CEREVISIAE
SEROLOGICAL RESPONSES
RISK
ANTIBODIES
AUTOIMMUNITY
CHILDREN
PREVALENCE
ASSOCIATION
CONCORDANCE
CHILDHOOD
3143 Nutrition
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