Breastfeeding may have a long-term effect on oral microbiota : results from the Fin-HIT cohort

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Eshriqui , I , Viljakainen , H T , Ferreira , S , Raju , S C , Weiderpass , E & Figueiredo , R A O 2020 , ' Breastfeeding may have a long-term effect on oral microbiota : results from the Fin-HIT cohort ' , International Breastfeeding Journal , vol. 15 , no. 1 , 42 . https://doi.org/10.1186/s13006-020-00285-w

Title: Breastfeeding may have a long-term effect on oral microbiota : results from the Fin-HIT cohort
Author: Eshriqui, Ilana; Viljakainen, Heli T.; Ferreira, Sandra; Raju, Sajan C.; Weiderpass, Elisabete; Figueiredo, Rejane A. O.
Contributor organization: Department of Food and Nutrition
HUS Children and Adolescents
University of Helsinki
Faculty of Medicine
Medicum
Helsinki Institute of Urban and Regional Studies (Urbaria)
Date: 2020-05-15
Language: eng
Number of pages: 11
Belongs to series: International Breastfeeding Journal
ISSN: 1746-4358
DOI: https://doi.org/10.1186/s13006-020-00285-w
URI: http://hdl.handle.net/10138/316203
Abstract: Background Breastfeeding contributes to gastrointestinal microbiota colonization in early life, but its long-term impact is inconclusive. We aimed to evaluate whether the type of feeding during the first six months of life was associated with oral microbiota in adolescence. Methods This is a cross-sectional sub-study using baseline information of 423 adolescents from the Finnish Health in Teens (Fin-HIT) cohort. Type of feeding was recalled by parents and dichotomized as (i) No infant formula; (ii) Infant formula (breastmilk + formula or only formula). Saliva microbiota was analysed using 16S rRNA (V3-V4) sequencing. Alpha diversity and beta diversity were compared between feeding type groups using ANCOVA and PERMANOVA, respectively. Differential bacteria abundance was tested using appropriate general linear models. Results Mean age and body mass index were 11.7 years and 18.0 kg/m(2), respectively. The No formula group contained 41% of the participants. Firmicutes (51.0%), Bacteroidetes (19.1%), and Proteobacteria (16.3%) were the most abundant phyla among all participants. Alpha and beta diversity indices did not differ between the two feeding groups. Three Operational Taxonomic Units (OTUs) belonging to Eubacteria and Veillonella genera (phylum Firmicutes) were more abundant in the No formula than in the Infant formula group (log2fold changes/ p - values - 0.920/ <0.001, - 0.328/ 0.001, - 0.577/ 0.004). Conclusion Differences exist in abundances of some OTUs in adolescence according to feeding type during the first six months of life, but our findings do not support diversity and overall oral microbiota composition in adolescents being affected by early feeding type.
Subject: Microbiota
Saliva
Breastfeeding
Adolescent
GUT MICROBIOTA
INTESTINAL MICROBIOTA
EARLY-LIFE
EARLY-CHILDHOOD
INFANTS
DISEASE
HEALTH
RISK
ESTABLISHMENT
ASSOCIATION
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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