Measurement of excitation-inhibition ratio in autism spectrum disorder using critical brain dynamics

Show simple item record

dc.contributor.author Bruining, Hilgo
dc.contributor.author Hardstone, Richard
dc.contributor.author Juarez-Martinez, Erika L.
dc.contributor.author Sprengers, Jan
dc.contributor.author Avramiea, Arthur-Ervin
dc.contributor.author Simpraga, Sonja
dc.contributor.author Houtman, Simon J.
dc.contributor.author Poil, Simon-Shlomo
dc.contributor.author Dallares, Eva
dc.contributor.author Palva, Satu
dc.contributor.author Oranje, Bob
dc.contributor.author Matias Palva, J.
dc.contributor.author Mansvelder, Huibert D.
dc.contributor.author Linkenkaer-Hansen, Klaus
dc.date.accessioned 2020-06-17T05:07:02Z
dc.date.available 2020-06-17T05:07:02Z
dc.date.issued 2020-06-08
dc.identifier.citation Bruining , H , Hardstone , R , Juarez-Martinez , E L , Sprengers , J , Avramiea , A-E , Simpraga , S , Houtman , S J , Poil , S-S , Dallares , E , Palva , S , Oranje , B , Matias Palva , J , Mansvelder , H D & Linkenkaer-Hansen , K 2020 , ' Measurement of excitation-inhibition ratio in autism spectrum disorder using critical brain dynamics ' , Scientific Reports , vol. 10 , no. 1 , 9195 . https://doi.org/10.1038/s41598-020-65500-4
dc.identifier.other PURE: 138996226
dc.identifier.other PURE UUID: 90c3dda0-2614-43c5-80de-01801040281b
dc.identifier.other Bibtex: Bruining2020
dc.identifier.other ORCID: /0000-0001-9496-7391/work/75942643
dc.identifier.other WOS: 000560458900007
dc.identifier.uri http://hdl.handle.net/10138/316217
dc.description cited By 0
dc.description.abstract Balance between excitation (E) and inhibition (I) is a key principle for neuronal network organization and information processing. Consistent with this notion, excitation-inhibition imbalances are considered a pathophysiological mechanism in many brain disorders including autism spectrum disorder (ASD). However, methods to measure E/I ratios in human brain networks are lacking. Here, we present a method to quantify a functional E/I ratio (fE/I) from neuronal oscillations, and validate it in healthy subjects and children with ASD. We define structural E/I ratio in an in silico neuronal network, investigate how it relates to power and long-range temporal correlations (LRTC) of the network's activity, and use these relationships to design the fE/I algorithm. Application of this algorithm to the EEGs of healthy adults showed that fE/I is balanced at the population level and is decreased through GABAergic enforcement. In children with ASD, we observed larger fE/I variability and stronger LRTC compared to typically developing children (TDC). Interestingly, visual grading for EEG abnormalities that are thought to reflect E/I imbalances revealed elevated fE/I and LRTC in ASD children with normal EEG compared to TDC or ASD with abnormal EEG. We speculate that our approach will help understand physiological heterogeneity also in other brain disorders. en
dc.format.extent 15
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3112 Neurosciences
dc.subject RANGE TEMPORAL CORRELATIONS
dc.subject NEURONAL AVALANCHES
dc.subject EXCITATION/INHIBITION BALANCE
dc.subject EPILEPTIFORM ABNORMALITIES
dc.subject FUNCTIONAL CONNECTIVITY
dc.subject GAMMA FREQUENCY
dc.subject RESTING GABA
dc.subject STATE
dc.subject NETWORKS
dc.subject OSCILLATIONS
dc.title Measurement of excitation-inhibition ratio in autism spectrum disorder using critical brain dynamics en
dc.type Article
dc.contributor.organization Neuroscience Center
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.contributor.organization University of Helsinki
dc.contributor.organization Matias Palva / Principal Investigator
dc.contributor.organization BioMag Laboratory
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization Helsinki University Hospital Area
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41598-020-65500-4
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_020_65500_4.pdf 5.123Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record