Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status

Show full item record



Permalink

http://hdl.handle.net/10138/316271

Citation

FinnDiane Study Grp , Parente , E B , Harjutsalo , V , Lehto , M , Forsblom , C , Sandholm , N & Groop , P-H 2020 , ' Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status ' , Cardiovascular Diabetology , vol. 19 , no. 1 , 68 . https://doi.org/10.1186/s12933-020-01038-z

Title: Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status
Author: FinnDiane Study Grp; Parente, Erika B.; Harjutsalo, Valma; Lehto, Markku; Forsblom, Carol; Sandholm, Niina; Groop, Per-Henrik
Contributor organization: CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
University of Helsinki
HUS Abdominal Center
Nefrologian yksikkö
Research Programs Unit
Medicum
Department of Medicine
Per Henrik Groop / Principal Investigator
Helsinki University Hospital Area
Date: 2020-05-19
Language: eng
Number of pages: 9
Belongs to series: Cardiovascular Diabetology
ISSN: 1475-2840
DOI: https://doi.org/10.1186/s12933-020-01038-z
URI: http://hdl.handle.net/10138/316271
Abstract: Background ABO blood groups have previously been associated with cardiovascular disease (CVD) in the general population. This study aimed to investigate the potential relationship between ABO blood groups and CVD in individuals with type 1 diabetes according to diabetic nephropathy (DN) status. Methods Adults with type 1 diabetes (4531 individuals) from the FinnDiane Study were evaluated. DN was determined by two out of three measurements of urinary albumin excretion rate. Albuminuria was defined as an excretion rate above 20 mu g/min. CVD events were identified by linking the data with the Finnish Care Register for Health Care and the Finnish Cause of Death Register. Follow-up ranged from the baseline visit until a CVD event, death or the end of 2017. The impact of ABO blood groups on CVD risk was estimated by multivariable Cox-regression analyses adjusted for traditional risk factors. Results At baseline, the median age was 38.5 (IQR 29.2-47.9) years, 47.5% were female and median duration of diabetes was 20.9 (11.4-30.7) years. There were 893 incident ischemic heart disease (IHD) events, 301 ischemic strokes (IS), and 415 peripheral artery disease (PAD) events during a median follow up of 16.5 (IQR 12.8-18.6) years. The A blood group showed the highest risk of IHD versus the O blood group, when microalbuminuria was present. Comparing the population with microalbuminuria with those with normoalbuminuria, only the A blood group elevated the risk of IHD. This increased risk was neither explained by the FUT2 secretor phenotype nor by the A-genotype distribution. The risk of IS or PAD was no different among the ABO blood groups regardless of diabetic nephropathy stage. Conclusion The A blood group is a risk factor for IHD in individuals with type 1 diabetes and microalbuminuria.
Subject: Type 1 diabetes
Diabetic nephropathy
Cardiovascular disease
Blood group
ARTERIAL-DISEASE
HEART-DISEASE
RISK
ASSOCIATION
ATHEROSCLEROSIS
MORTALITY
SEQUENCE
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
document.pdf 748.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record