NON-INVASIVE VASCULAR VERY-HIGH RESOLUTION ULTRASOUND TO QUANTIFY ARTERY INTIMA LAYER THICKNESS : VALIDATION OF THE FOUR-LINE PATTERN

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Sundholm , J K M , Paetau , A , Albäck , A , Pettersson , T & Sarkola , T 2019 , ' NON-INVASIVE VASCULAR VERY-HIGH RESOLUTION ULTRASOUND TO QUANTIFY ARTERY INTIMA LAYER THICKNESS : VALIDATION OF THE FOUR-LINE PATTERN ' , Ultrasound in Medicine & Biology , vol. 45 , no. 8 , pp. 2010-2018 . https://doi.org/10.1016/j.ultrasmedbio.2019.04.017

Title: NON-INVASIVE VASCULAR VERY-HIGH RESOLUTION ULTRASOUND TO QUANTIFY ARTERY INTIMA LAYER THICKNESS : VALIDATION OF THE FOUR-LINE PATTERN
Author: Sundholm, Johnny K. M.; Paetau, Anders; Albäck, Anders; Pettersson, Tom; Sarkola, Taisto
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUSLAB
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, HUS Children and Adolescents
Date: 2019-08
Language: eng
Number of pages: 9
Belongs to series: Ultrasound in Medicine & Biology
ISSN: 0301-5629
URI: http://hdl.handle.net/10138/316310
Abstract: Preliminary findings suggest that very-high resolution ultrasound (VHRU, 55 MHz) could differentiate arterial intima layer thickness (IT) non-invasively in vivo. We aimed to validate ultrasound-derived IT measurements and describe a four-line pattern consistent with intimal thickening. VHRU was applied to temporal arteries of 37 patients with suspected giant cell arteritis without inflammation on histology. Anatomically matched ultrasound-derived measurements of arterial layer thickness with the leading-edge method was compared to histology. Intimal thickening (IT >0.06 mm on histology) was identified as a four-line pattern in VHRU with a sensitivity of 96.3% and a specificity of 100%. Histologic and VHRU IT measurement agreement was excellent (mean difference 0.007 mm; 95% limits of agreement, -0.043 to 0.057) and intra-class coefficient (ICC) 0.923 (95% confidence interval [CI], 0.833-0.964). Intra- and inter-observer agreements for VHRU IT were high: ICC 0.946 (95% CI, 0.877-0.976) and 0.872 (95% CI, 0.773-0.943). VHRU utilizing the leading-to-leading edge method allows accurate and reliable measurements of arterial IT in patients with IT >0.06 mm. Measurements of IT will provide the opportunity to explore early subclinical structural intimal changes in the arterial wall increasing with age. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
Subject: Vascular imaging
Intima thickness
Intima-media thickness
Ultrasound biomicroscopy
Methodology
Very-high resolution ultrasound
MEDIA THICKNESS
WALL THICKNESS
CAROTID-ARTERY
RISK
PRINCIPLES
CHILDHOOD
DISEASE
STROKE
3126 Surgery, anesthesiology, intensive care, radiology
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