Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

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Lowry , E , Rautio , N , Wasenius , N , Bond , T A , Lahti , J , Tzoulaki , I , Dehghan , A , Heiskala , A , Ala-Mursula , L , Miettunen , J , Eriksson , J , Järvelin , M-R & Sebert , S 2020 , ' Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts ' , BMC Public Health , vol. 20 , no. 1 , 708 . https://doi.org/10.1186/s12889-020-08763-w

Title: Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts
Author: Lowry, Estelle; Rautio, Nina; Wasenius, Niko; Bond, Tom A.; Lahti, Jari; Tzoulaki, Ioanna; Dehghan, Abbas; Heiskala, Anni; Ala-Mursula, Leena; Miettunen, Jouko; Eriksson, Johan; Järvelin, Marjo-Riitta; Sebert, Sylvain
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Clinicum
Date: 2020-05-18
Language: eng
Number of pages: 12
Belongs to series: BMC Public Health
ISSN: 1471-2458
URI: http://hdl.handle.net/10138/316319
Abstract: BackgroundThe study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI.MethodsWe studied participants of Helsinki Birth Cohort Study born in 1934-1944 (HBCS1934-1944, n=1277) and Northern Finland Birth Cohorts born in 1966 and 1986 (NFBC1966, n=5807, NFBC1986, n=6717). Factor analysis produced scores of social disadvantage based on social and economic elements in early life and adulthood/over the life course, and was categorized as high, intermediate and low. BMI was measured at 62years in HBCS1934-1944, at 46years in NFBC1966 and at 16years in NFBC1986. Multivariable linear regression analysis was used to explore associations between social disadvantages and BMI after adjustments for polygenic risk score for BMI (PRS BMI), maternal BMI and sex.ResultsThe association between exposure to high early social disadvantage and increased later life BMI persisted after adjustments (beta =0.79, 95% CI, 0.33, 1.25, p 0.22, 95% CI -0.91,1.35, p=0.700). In HBCS1934-1944 and NFBC1966, participants who had reduced their exposure to social disadvantage during the life-course had lower later life BMI than those who had increased their exposure (beta -1.34, [-2.37,-0.31], p=0.011; beta -0.46, [-0.89,-0.03], p=0.038, respectively).ConclusionsHigh social disadvantage in early life appears to be associated with higher BMI in later life. Reducing exposure to social disadvantage during the life-course may be a potential pathway for obesity reduction.
Subject: Early life
Social disadvantage
Body mass index (BMI)
Maternal
Polygenic risk score for BMI
CHILDHOOD SOCIOECONOMIC POSITION
ADULT OBESITY
PREDICTORS
MOBILITY
METAANALYSIS
3142 Public health care science, environmental and occupational health
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