Brain interstitial pH changes in the subacute phase of hypoxic-ischemic encephalopathy in newborn pigs

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Remzső , G , Németh , J , Varga , V , Kovács , V , Tóth-Szűki , V , Kaila , K , Voipio , J & Domoki , F 2020 , ' Brain interstitial pH changes in the subacute phase of hypoxic-ischemic encephalopathy in newborn pigs ' , PLoS One , vol. 15 , no. 5 , 0233851 . https://doi.org/10.1371/journal.pone.0233851

Title: Brain interstitial pH changes in the subacute phase of hypoxic-ischemic encephalopathy in newborn pigs
Author: Remzső, Gábor; Németh, János; Varga, Viktória; Kovács, Viktória; Tóth-Szűki, Valéria; Kaila, Kai; Voipio, Juha; Domoki, Ferenc
Contributor: University of Helsinki, Physiology and Neuroscience
University of Helsinki, Physiology and Neuroscience
Date: 2020-05-29
Language: eng
Number of pages: 15
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/316905
Abstract: Brain interstitial pH (pHbrain) alterations play an important role in the mechanisms of neuronal injury in neonatal hypoxic-ischemic encephalopathy (HIE) induced by perinatal asphyxia. The newborn pig is an established large animal model to study HIE, however, only limited information on pHbrain alterations is available in this species and it is restricted to experimental perinatal asphyxia (PA) and the immediate reventilation. Therefore, we sought to determine pHbrain over the first 24h of HIE development in piglets. Anaesthetized, ventilated newborn pigs (n = 16) were instrumented to control major physiological parameters. pHbrain was determined in the parietal cortex using a pH-selective microelectrode. PA was induced by ventilation with a gas mixture containing 6%O2-20%CO2 for 20 min, followed by reventilation with air for 24h, then the brains were processed for histopathology assessment. The core temperature was maintained unchanged during PA (38.4±0.1 vs 38.3±0.1°C, at baseline versus the end of PA, respectively; mean±SEM). In the arterial blood, PA resulted in severe hypoxia (PaO2: 65±4 vs 23±1*mmHg, *p
Subject: 3112 Neurosciences
NEONATAL ENCEPHALOPATHY
ENERGY-METABOLISM
INTRACELLULAR PH
PLASMA-GLUCOSE
BLOOD-FLOW
PIGLET
INFANTS
MODEL
PCO2
ASPHYXIA
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