Interictal magnetoencephalography in parietal lobe epilepsy – comparison of equivalent current dipole and beamformer (SAMepi) analysis

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Wilenius , J , Lauronen , L , Kirveskari , E , Gaily , E , Metsähonkala , L & Paetau , R 2020 , ' Interictal magnetoencephalography in parietal lobe epilepsy – comparison of equivalent current dipole and beamformer (SAMepi) analysis ' , Clinical neurophysiology practice , vol. 5 , pp. 64-72 . https://doi.org/10.1016/j.cnp.2020.02.003

Title: Interictal magnetoencephalography in parietal lobe epilepsy – comparison of equivalent current dipole and beamformer (SAMepi) analysis
Author: Wilenius, Juha; Lauronen, Leena; Kirveskari, Erika; Gaily, Eija; Metsähonkala, Liisa; Paetau, Ritva
Contributor organization: HUSLAB
HUS Medical Imaging Center
BioMag Laboratory
Kliinisen neurofysiologian yksikkö
University of Helsinki
Helsinki University Hospital Area
Clinicum
HUS Children and Adolescents
Department of Neurosciences
Children's Hospital
Lastenneurologian yksikkö
Date: 2020-03-10
Language: eng
Number of pages: 9
Belongs to series: Clinical neurophysiology practice
ISSN: 2467-981X
DOI: https://doi.org/10.1016/j.cnp.2020.02.003
URI: http://hdl.handle.net/10138/316923
Abstract: Objective To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity in parietal lobe epilepsy (PLE) patients in comparison with equivalent current dipole (ECD) analysis. Methods We analyzed the preoperative interictal MEG of 17 operated PLE patients utilizing visual analysis and: (1) ECD with a spherical conductor model; (2) ECD with a boundary element method (BEM) conductor model; and (3) SAMepi - a kurtosis beamformer method. Localization results were compared between the three methods, to the location of the resection and to the clinical outcome. Results Fourteen patients had an epileptiform finding in the visual analysis; SAMepi detected spikes in 11 of them. A unifocal finding in both the ECD and in the SAMepi analysis was associated with a better chance of seizure-freedom (p=0.02). There was no significant difference in the distances from the unifocal MEG localizations to the nearest border of the resection between the different analysis methods. Conclusions Localizations of unifocal interictal spikes detected by SAMepi did not significantly differ from the conventional ECD localizations. Significance SAMepi - a novel semiautomatic analysis method - is useful in localizing interictal epileptiform MEG activity in the presurgical evaluation of parietal lobe epilepsy patients.
Subject: epilepsy surgery
magnetoencephalography
interictal
parietal lobe
equivalent current dipole
beamformer
3124 Neurology and psychiatry
3112 Neurosciences
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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