Effects of Long-Term Paired Associative Stimulation on Strength of Leg Muscles and Walking in Chronic Tetraplegia : A Proof-of-Concept Pilot Study

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dc.contributor.author Rodionov, Andrei
dc.contributor.author Savolainen, Sarianna
dc.contributor.author Kirveskari, Erika
dc.contributor.author Mäkelä, Jyrki P.
dc.contributor.author Shulga, Anastasia
dc.date.accessioned 2020-06-25T14:09:01Z
dc.date.available 2020-06-25T14:09:01Z
dc.date.issued 2020-05-20
dc.identifier.citation Rodionov , A , Savolainen , S , Kirveskari , E , Mäkelä , J P & Shulga , A 2020 , ' Effects of Long-Term Paired Associative Stimulation on Strength of Leg Muscles and Walking in Chronic Tetraplegia : A Proof-of-Concept Pilot Study ' , Frontiers in neurology , vol. 11 , 397 . https://doi.org/10.3389/fneur.2020.00397
dc.identifier.other PURE: 139557326
dc.identifier.other PURE UUID: 0c960083-49e4-45d7-a2e2-610811cee872
dc.identifier.other WOS: 000539324500001
dc.identifier.other ORCID: /0000-0003-0262-3570/work/76330203
dc.identifier.other ORCID: /0000-0002-4603-9555/work/76334202
dc.identifier.uri http://hdl.handle.net/10138/316979
dc.description.abstract Recovery of lower-limb function after spinal cord injury (SCI) is dependent on the extent of remaining neural transmission in the corticospinal pathway. The aim of this proof-of-concept pilot study was to explore the effects of long-term paired associative stimulation (PAS) on leg muscle strength and walking in people with SCI. Five individuals with traumatic incomplete chronic tetraplegia (>34 months post-injury, motor incomplete, 3 females, mean age 60 years) with no contraindications to transcranial magnetic stimulation (TMS) received PAS to one or both legs for 2 months (28 sessions in total, 5 times a week for the first 2 weeks and 3 times a week thereafter). The participants were evaluated with the Manual Muscle Test (MMT), AIS motor and sensory examination, Modified Asworth Scale (MAS), and the Spinal Cord Independence Measure (SCIM) prior to the intervention, after 1 and 2 months of PAS, and after a 1-month follow-up. The study was registered at (NCT03459885). During the intervention, MMT scores and AIS motor scores increased significantly (p = 0.014 and p = 0.033, respectively). Improvements were stable in follow-up. AIS sensory scores, MAS, and SCIM were not modified significantly. MMT score prior to intervention was a good predictor of changes in walking speed (Radj2 = 0.962). The results of this proof-of-concept pilot study justify a larger trial on the effect of long-term PAS on leg muscle strength and walking in people with chronic incomplete SCI. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Frontiers in neurology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject paired associative stimulation
dc.subject walking
dc.subject TMS
dc.subject spinal cord injury
dc.subject neuroplasticity
dc.subject SPINAL-CORD-INJURY
dc.subject NONINVASIVE BRAIN-STIMULATION
dc.subject MOTOR CORTEX
dc.subject PLASTICITY
dc.subject EXCITABILITY
dc.subject INDUCTION
dc.subject RECOVERY
dc.subject NERVE
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Effects of Long-Term Paired Associative Stimulation on Strength of Leg Muscles and Walking in Chronic Tetraplegia : A Proof-of-Concept Pilot Study en
dc.type Article
dc.contributor.organization BioMag Laboratory
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization Kliinisen neurofysiologian yksikkö
dc.contributor.organization Department of Neurosciences
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Neurologian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/fneur.2020.00397
dc.relation.issn 1664-2295
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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