Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring

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http://hdl.handle.net/10138/316989

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Helle , E & Priest , J R 2020 , ' Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring ' , Journal of the American Heart Association , vol. 9 , no. 8 , 011541 . https://doi.org/10.1161/JAHA.119.011541

Title: Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring
Author: Helle, Emmi; Priest, James R.
Contributor: University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
Date: 2020-04-21
Language: eng
Number of pages: 9
Belongs to series: Journal of the American Heart Association
ISSN: 2047-9980
URI: http://hdl.handle.net/10138/316989
Abstract: Congenital heart disease (CHD) is the most common anatomical malformation occurring live-born infants and an increasing cause of morbidity and mortality across the lifespan and throughout the world. Population-based observations have long described associations between maternal cardiometabolic disorders and the risk of CHD in the offspring. Here we review the epidemiological evidence and clinical observations relating maternal obesity and diabetes mellitus to the risk of CHD offspring with particular attention to mechanistic models of maternal-fetal risk transmission and first trimester disturbances of fetal cardiac development. A deeper understanding of maternal risk factors holds the potential to improve both prenatal detection of CHD by identifying at-risk pregnancies, along with primary prevention of disease by improving preconception and prenatal treatment of at-risk mothers.
Subject: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
cardiometabolic
congenital heart disease
maternal diabetes mellitus
maternal obesity
BODY-MASS INDEX
NEURAL CREST CELLS
NITRIC-OXIDE
BIRTH-DEFECTS
BETA-HYDROXYBUTYRATE
CARDIAC-SURGERY
ADIPOSE-TISSUE
RAT EMBRYOS
GLUCOSE
WOMEN
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