Birth cohort effects on the quantity and heritability of alcohol consumption in adulthood : a Finnish longitudinal twin study

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http://hdl.handle.net/10138/317085

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Virtanen , S , Kaprio , J , Viken , R , Rose , R J & Latvala , A 2019 , ' Birth cohort effects on the quantity and heritability of alcohol consumption in adulthood : a Finnish longitudinal twin study ' , Addiction , vol. 114 , no. 5 , pp. 836-846 . https://doi.org/10.1111/add.14533

Title: Birth cohort effects on the quantity and heritability of alcohol consumption in adulthood : a Finnish longitudinal twin study
Author: Virtanen, Suvi; Kaprio, Jaakko; Viken, Richard; Rose, Richard J.; Latvala, Antti
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-05
Language: eng
Number of pages: 11
Belongs to series: Addiction
ISSN: 0965-2140
URI: http://hdl.handle.net/10138/317085
Abstract: Aims To estimate birth cohort effects on alcohol consumption and abstinence in Finland and to test differences between birth cohorts in genetic and environmental sources of variation in Finnish adult alcohol use. Design The Older Finnish Twin Cohort longitudinal survey study 1975-2011. Setting Finland. Participants A total of 26 121 same-sex twins aged 18-95 years (full twin pairs at baseline n = 11 608). Measurements Outcome variables were the quantity of alcohol consumption (g/month) and abstinence (drinking zero g/month). Predictor variables were 10-year birth cohort categories and socio-demographic covariates. In quantitative genetic models, two larger cohorts (born 1901-20 and 1945-57) were compared. Findings Multi-level models in both sexes indicated higher levels of alcohol consumption in more recent birth cohorts and lower levels in earlier cohorts, compared with twins born 1921-30 (all P < 0.003). Similarly, compared with twins born 1921-30, abstaining was more common in earlier and less common in more recent cohorts (all P < 0.05), with the exception of men born 1911-20. Birth cohort differences in the genetic and environmental variance components in alcohol consumption were found: heritability was 21% [95% confidence interval (CI) = 0-56%] in the earlier-born cohort of women [mean age 62.8, standard deviation (SD) = 5.3] and 51% (95% CI = 36-56%) in a more recent cohort (mean age 60.2, SD = 3.7) at the age of 54-74. For men, heritability was 39% (95% CI = 27-45%) in both cohorts. In alcohol abstinence, environmental influences shared between co-twins explained a large proportion of variation in the earlier-born cohort (43%, 95% CI = 23-63%), whereas non-shared environmental (54%, 95% CI = 39-72%) and additive genetic influences (40%, 95% CI = 13-61%) were more important among more recent cohorts of men and women. Conclusion The contribution of genetic and environmental variability to variability in alcohol consumption in the Finnish population appears to vary by birth cohort.
Subject: 3124 Neurology and psychiatry
3142 Public health care science, environmental and occupational health
Abstinence
alcohol use
cohort study
environment
heritability
longitudinal
twins
GENE-ENVIRONMENT INTERACTION
GENDER-DIFFERENCES
DRINKING PATTERNS
AGE
PERIOD
POPULATION
TRENDS
INITIATION
DRINKERS
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