High risk of metabolic syndrome after delivery in pregnancies complicated by gestational diabetes

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Shen , Y , Li , W , Leng , J , Zhang , S , Liu , H , Li , W , Wang , L , Tian , H , Chen , J , Qi , L , Yang , X , Yu , Z , Tuomilehto , J & Hu , G 2019 , ' High risk of metabolic syndrome after delivery in pregnancies complicated by gestational diabetes ' , Diabetes Research and Clinical Practice , vol. 150 , pp. 219-226 . https://doi.org/10.1016/j.diabres.2019.03.030

Title: High risk of metabolic syndrome after delivery in pregnancies complicated by gestational diabetes
Author: Shen, Yun; Li, Weiqin; Leng, Junhong; Zhang, Shuang; Liu, Huikun; Li, Wei; Wang, Leishen; Tian, Huiguang; Chen, Jinbo; Qi, Lu; Yang, Xilin; Yu, Zhijie; Tuomilehto, Jaakko; Hu, Gang
Contributor: University of Helsinki, Clinicum
Date: 2019-04
Language: eng
Number of pages: 8
Belongs to series: Diabetes Research and Clinical Practice
ISSN: 0168-8227
URI: http://hdl.handle.net/10138/317091
Abstract: Aims: To investigate the risk of postpartum metabolic syndrome in women with GDM compared with those without GDM in a Chinese population. Methods: Tianjin GDM observational study included 1263 women with a history of GDM and 705 women without GDM. Multivariate logistic regression was used to assess risks of postpartum metabolic syndrome between women with and without GDM. Postpartum metabolic syndrome was diagnosed by two commonly used criteria. Results: During a mean 3.53 years of follow up, 256 cases of metabolic syndrome were identified by using the NCEPATPIII criteria and 244 cases by using the IDF criteria. Multivariable-adjusted odds ratios of metabolic syndrome in women with GDM compared with those without GDM were 3.66 (95% confidence interval [CI] 2.02-6.63) for NCEP ATPIII criteria and 3.90 (95% CI 2.13-7.14) for IDF criteria. Women with GDM had higher multivariable-adjusted odds ratios of central obesity, hypertriglyceridemia, and high blood pressure than women without GDM. The multivariable-adjusted odds ratios of low HDL cholesterol and hyperglycemia were not significant between women with and without GDM, however, the multivariable-adjusted odds ratio of hyperglycemia became significant when we used the modified criteria. Conclusions: The present study indicated that women with prior GDM had significantly higher risks for postpartum metabolic syndrome, as well as its individual components. (C) 2019 Elsevier B.V. All rights reserved.
Subject: Gestational diabetes mellitus
Postpartum
Metabolic syndrome
CHINESE WOMEN
CARDIOVASCULAR-DISEASE
POSTPARTUM RISK
ALL-CAUSE
PREVALENCE
MELLITUS
MORTALITY
GLUCOSE
POPULATION
DIAGNOSIS
3121 Internal medicine
3142 Public health care science, environmental and occupational health
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