Fine-Scale Haplotype Structure Reveals Strong Signatures of Positive Selection in a Recombining Bacterial Pathogen

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http://hdl.handle.net/10138/317197

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Arnold , B , Sohail , M , Wadsworth , C , Corander , J , Hanage , W P , Sunyaev , S & Grad , Y H 2020 , ' Fine-Scale Haplotype Structure Reveals Strong Signatures of Positive Selection in a Recombining Bacterial Pathogen ' , Molecular Biology and Evolution , vol. 37 , no. 2 , pp. 417-428 . https://doi.org/10.1093/molbev/msz225

Title: Fine-Scale Haplotype Structure Reveals Strong Signatures of Positive Selection in a Recombining Bacterial Pathogen
Author: Arnold, Brian; Sohail, Mashaal; Wadsworth, Crista; Corander, Jukka; Hanage, William P.; Sunyaev, Shamil; Grad, Yonatan H.
Contributor: University of Helsinki, Helsinki Institute for Information Technology
Date: 2020-02
Language: eng
Number of pages: 12
Belongs to series: Molecular Biology and Evolution
ISSN: 0737-4038
URI: http://hdl.handle.net/10138/317197
Abstract: Identifying genetic variation in bacteria that has been shaped by ecological differences remains an important challenge. For recombining bacteria, the sign and strength of linkage provide a unique lens into ongoing selection. We show that derived alleles
Subject: evolutionary genetics
microbiology
computational biology
simulation
adaptation
linkage
NEISSERIA-GONORRHOEAE
LINKAGE DISEQUILIBRIUM
GENOMIC EPIDEMIOLOGY
SEQUENCE
RESISTANCE
EVOLUTION
DNA
TRANSFORMATION
POPULATIONS
MUTATIONS
1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology
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