Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

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Thibau , A , Dichter , A A , Vaca , D J , Linke , D , Goldman , A & Kempf , V A J 2020 , ' Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets ' , Medical Microbiology and Immunology , vol. 209 , no. 3 , pp. 243-263 . https://doi.org/10.1007/s00430-019-00649-y

Title: Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets
Author: Thibau, Arno; Dichter, Alexander A.; Vaca, Diana J.; Linke, Dirk; Goldman, Adrian; Kempf, Volkhard A. J.
Contributor organization: Molecular and Integrative Biosciences Research Programme
Date: 2020-06
Language: eng
Number of pages: 21
Belongs to series: Medical Microbiology and Immunology
ISSN: 0300-8584
DOI: https://doi.org/10.1007/s00430-019-00649-y
URI: http://hdl.handle.net/10138/317211
Abstract: The current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular environment. Trimeric autotransporter adhesins (TAAs) are important virulence factors in many Gram-negative bacteria, are localised on the bacterial surface, and mediate the first adherence to host cells in the course of infection. One example is the Neisseria adhesin A (NadA), which is currently used as a subunit in a licensed vaccine against Neisseria meningitidis. Other TAAs that seem promising vaccine candidates are the Acinetobacter trimeric autotransporter (Ata), the Haemophilus influenzae adhesin (Hia), and TAAs of the genus Bartonella. Here, we review the suitability of various TAAs as vaccine candidates.
Subject: 11832 Microbiology and virology
3111 Biomedicine
Trimeric autotransporter adhesins
Immunogenicity
Vaccination
Pathogenicity
Virulence
OUTER-MEMBRANE PROTEINS
ENTEROTOXIGENIC ESCHERICHIA-COLI
NEISSERIA-MENINGITIDIS ADHESIN
IMMUNOGLOBULIN-BINDING PROTEIN
B CONJUGATE VACCINE
MORAXELLA-CATARRHALIS
YERSINIA-ENTEROCOLITICA
BARTONELLA-HENSELAE
ACINETOBACTER-BAUMANNII
SERUM RESISTANCE
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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