Sub-chronic toxicity evaluation of top three commercial herbal antimalarial preparations in the Kumasi metropolis, Ghana

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Adusei-Mensah , F , Tikkanen-Kaukanen , C , Kauhanen , J , Henneh , I T , Agyei , P E O , Akakpo , P K & Ekor , M 2020 , ' Sub-chronic toxicity evaluation of top three commercial herbal antimalarial preparations in the Kumasi metropolis, Ghana ' , Bioscience Reports , vol. 40 , no. 6 , 20192536 . https://doi.org/10.1042/BSR20192536

Title: Sub-chronic toxicity evaluation of top three commercial herbal antimalarial preparations in the Kumasi metropolis, Ghana
Author: Adusei-Mensah, Frank; Tikkanen-Kaukanen, Carina; Kauhanen, Jussi; Henneh, Isaac Tabiri; Agyei, Phyllis Elsie Owusu; Akakpo, Patrick Kafui; Ekor, Martins
Contributor: University of Helsinki, Ruralia Institute, Mikkeli
Date: 2020-06-05
Language: eng
Number of pages: 16
Belongs to series: Bioscience Reports
ISSN: 0144-8463
URI: http://hdl.handle.net/10138/317343
Abstract: Purpose: Safety data on commonly used herbal medicinal (HM) products (HMPs) and marketed in Ghana are scarce. We assessed the sub-chronic toxicity of three most-patronised commercial antimalarial HMPs in Kumasi, Ghana. Method: Top three HMPs (designated as herbal products 'A' (HPA), 'B' (HPB) and 'C' (HPC)) were selected after a mini-survey and sub-chronic toxicity evaluation conducted in accordance with Organisation for Economic Co-operation and Development (OECD) 407 guidelines. Control rats received clean water while test groups received daily adult human dose (DAHD), 5x DAHD or 10x DAHD of either HPA, HPB or HPC for 30 days. Rats were killed on day 31 to obtain biochemical, haematology and histology samples for analysis. Data were analysed by one-way analysis of variance (ANOVA) and post hoc Tukey's test. Results: The three HMPs produced alterations in liver morphology predominantly characterised by prominent foci of fatty change with scattered hepatocytes containing intracytoplasmic fat globules and congested central veins and sinusoids. The lungs showed alveolar with evidence of inflammation and foci of epithelial sloughing. Alveolar spaces were also obscured by debris and inflammatory cells. HPA and HPC produced scattered intensely congested heart vessels while HPB(10) produced haemorrhage and amorphous exudates within the heart. All HMPs produced neither treatment-related deaths nor significant change in haematological and biochemical parameters, except for HPA and HPB which decreased (P Conclusion: Data from the present study suggest the potential of the herbal products (HPs), HPA, HPB and HPC, to cause major organ-system dysfunction or damage. We advise cautious use of these products and recommend further safety evaluation in chronic toxicity models.
Subject: 119 Other natural sciences
317 Pharmacy
1182 Biochemistry, cell and molecular biology
EXTRACT
WATER
PATHOLOGY
EXPOSURE
RODENT
INJURY
LEAVES
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