Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

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Shishido , T K , Popin , R V , Jokela , J , Wahlsten , M , Fiore , M F , Fewer , D P , Herfindal , L & Sivonen , K 2020 , ' Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria ' , Toxins , vol. 12 , no. 1 , 12 . https://doi.org/10.3390/toxins12010012

Title: Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria
Author: Shishido, Tania Keiko; Popin, Rafael Vicentini; Jokela, Jouni; Wahlsten, Matti; Fiore, Marli Fatima; Fewer, David P.; Herfindal, Lars; Sivonen, Kaarina
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Department of Microbiology
University of Helsinki, Department of Microbiology
University of Helsinki, Department of Microbiology
University of Helsinki, Department of Microbiology
University of Helsinki, Department of Microbiology
Date: 2020-01
Language: eng
Number of pages: 17
Belongs to series: Toxins
ISSN: 2072-6651
URI: http://hdl.handle.net/10138/317362
Abstract: Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.
Subject: natural products
mass spectrometry
leukemia
antifungal
antibacterial
cyanotoxins
Nostoc
MARINE CYANOBACTERIA
GEN. NOV
MOLECULAR-MECHANISMS
COMPARATIVE GENOMICS
PROTEASE INHIBITORS
MASS-SPECTROMETRY
CYCLIC PEPTIDE
CELL-LINES
DIVERSITY
APOPTOSIS
11832 Microbiology and virology
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