Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

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Pysyväisosoite

http://hdl.handle.net/10138/317362

Lähdeviite

Shishido , T K , Popin , R V , Jokela , J , Wahlsten , M , Fiore , M F , Fewer , D P , Herfindal , L & Sivonen , K 2020 , ' Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria ' , Toxins , vol. 12 , no. 1 , 12 . https://doi.org/10.3390/toxins12010012

Julkaisun nimi: Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria
Tekijä: Shishido, Tania Keiko; Popin, Rafael Vicentini; Jokela, Jouni; Wahlsten, Matti; Fiore, Marli Fatima; Fewer, David P.; Herfindal, Lars; Sivonen, Kaarina
Tekijän organisaatio: Institute of Biotechnology
Department of Microbiology
Department of Food and Nutrition
Cyanobacteria research
Helsinki Institute of Sustainability Science (HELSUS)
Microbial Natural Products
Päiväys: 2020-01
Kieli: eng
Sivumäärä: 17
Kuuluu julkaisusarjaan: Toxins
ISSN: 2072-6651
DOI-tunniste: https://doi.org/10.3390/toxins12010012
URI: http://hdl.handle.net/10138/317362
Tiivistelmä: Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.
Avainsanat: natural products
mass spectrometry
leukemia
antifungal
antibacterial
cyanotoxins
Nostoc
MARINE CYANOBACTERIA
GEN. NOV
MOLECULAR-MECHANISMS
COMPARATIVE GENOMICS
PROTEASE INHIBITORS
MASS-SPECTROMETRY
CYCLIC PEPTIDE
CELL-LINES
DIVERSITY
APOPTOSIS
11832 Microbiology and virology
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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