Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

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dc.contributor.author Shishido, Tania Keiko
dc.contributor.author Popin, Rafael Vicentini
dc.contributor.author Jokela, Jouni
dc.contributor.author Wahlsten, Matti
dc.contributor.author Fiore, Marli Fatima
dc.contributor.author Fewer, David P.
dc.contributor.author Herfindal, Lars
dc.contributor.author Sivonen, Kaarina
dc.date.accessioned 2020-07-06T10:06:02Z
dc.date.available 2020-07-06T10:06:02Z
dc.date.issued 2020-01
dc.identifier.citation Shishido , T K , Popin , R V , Jokela , J , Wahlsten , M , Fiore , M F , Fewer , D P , Herfindal , L & Sivonen , K 2020 , ' Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria ' , Toxins , vol. 12 , no. 1 , 12 . https://doi.org/10.3390/toxins12010012
dc.identifier.other PURE: 140158014
dc.identifier.other PURE UUID: 47cb241a-0ab6-4ae7-a7e3-fbcf09d2b6be
dc.identifier.other WOS: 000514630000010
dc.identifier.other ORCID: /0000-0003-3978-4845/work/77085796
dc.identifier.other ORCID: /0000-0001-5096-3575/work/77086720
dc.identifier.other ORCID: /0000-0002-2904-0458/work/77086848
dc.identifier.other ORCID: /0000-0002-4107-1695/work/77087585
dc.identifier.other ORCID: /0000-0003-0427-0326/work/77090466
dc.identifier.uri http://hdl.handle.net/10138/317362
dc.description.abstract Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments. en
dc.format.extent 17
dc.language.iso eng
dc.relation.ispartof Toxins
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject natural products
dc.subject mass spectrometry
dc.subject leukemia
dc.subject antifungal
dc.subject antibacterial
dc.subject cyanotoxins
dc.subject Nostoc
dc.subject MARINE CYANOBACTERIA
dc.subject GEN. NOV
dc.subject MOLECULAR-MECHANISMS
dc.subject COMPARATIVE GENOMICS
dc.subject PROTEASE INHIBITORS
dc.subject MASS-SPECTROMETRY
dc.subject CYCLIC PEPTIDE
dc.subject CELL-LINES
dc.subject DIVERSITY
dc.subject APOPTOSIS
dc.subject 11832 Microbiology and virology
dc.title Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria en
dc.type Article
dc.contributor.organization Institute of Biotechnology
dc.contributor.organization Department of Microbiology
dc.contributor.organization Department of Food and Nutrition
dc.contributor.organization Cyanobacteria research
dc.contributor.organization Helsinki Institute of Sustainability Science (HELSUS)
dc.contributor.organization Microbial Natural Products
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/toxins12010012
dc.relation.issn 2072-6651
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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