A Biomimetic 3D-Self-Forming Approach for Microvascular Scaffolds

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http://hdl.handle.net/10138/317388

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Zhang , L , Xiang , Y , Zhang , H , Cheng , L , Mao , X , An , N , Zhang , L , Zhou , J , Deng , L , Zhang , Y , Sun , X , Santos , H A & Cui , W 2020 , ' A Biomimetic 3D-Self-Forming Approach for Microvascular Scaffolds ' , Advanced Science , vol. 7 , no. 9 , 1903553 . https://doi.org/10.1002/advs.201903553

Title: A Biomimetic 3D-Self-Forming Approach for Microvascular Scaffolds
Author: Zhang, Liucheng; Xiang, Yi; Zhang, Hongbo; Cheng, Liying; Mao, Xiyuan; An, Ning; Zhang, Lu; Zhou, Jinxiong; Deng, Lianfu; Zhang, Yuguang; Sun, Xiaoming; Santos, Hélder A.; Cui, Wenguo
Contributor: University of Helsinki, Helsinki One Health (HOH)
Date: 2020-05-06
Language: eng
Number of pages: 10
Belongs to series: Advanced Science
ISSN: 2198-3844
URI: http://hdl.handle.net/10138/317388
Abstract: The development of science and technology often drew lessons from natural phenomena. Herein, inspired by drying-driven curling of apple peels, hydrogel-based micro-scaled hollow tubules (MHTs) are proposed for biomimicking microvessels, which promote microcirculation and improve the survival of random skin flaps. MHTs with various pipeline structures are fabricated using hydrogel in corresponding shapes, such as Y-branches, anastomosis rings, and triangle loops. Adjustable diameters can be achieved by altering the concentration and cross-linking time of the hydrogel. Based on this rationale, biomimetic microvessels with diameters of 50-500 mu m are cultivated in vitro by coculture of MHTs and human umbilical vein endothelial cells. In vivo studies show their excellent performance to promote microcirculation and improve the survival of random skin flaps. In conclusion, the present work proposes and validifies a biomimetic 3D self-forming method for the fabrication of biomimetic vessels and microvascular scaffolds with high biocompatibility and stability based on hydrogel materials, such as gelatin and hyaluronic acid.
Subject: CELLS
CHITOSAN
HYDROGEL
SKIN FLAP
VASCULARIZATION
bioinspired materials
biomimetic microvessels
self-forming
vascular scaffolds
318 Medical biotechnology
317 Pharmacy
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