Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis

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Sorsa , T , Bacigalupo , J , Könönen , M , Pärnänen , P & Räisänen , I T 2020 , ' Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis ' , Biosensors , vol. 10 , no. 5 , 44 .

Title: Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis
Author: Sorsa, Timo; Bacigalupo, Joseph; Könönen, Mauno; Pärnänen, Pirjo; Räisänen, Ismo T.
Contributor organization: HUS Head and Neck Center
Department of Oral and Maxillofacial Diseases
Timo Sorsa / Principal Investigator
Suu- ja leukakirurgian yksikkö
University of Helsinki
Helsinki University Hospital Area
Date: 2020-05
Language: eng
Number of pages: 7
Belongs to series: Biosensors
ISSN: 2079-6374
Abstract: Previous studies report periodontitis and peri-implantitis being able to induce systemic low-grade inflammation, which is known to be associated with increased risk for some systemic medical disease such as cardiovascular disease. In this regard, recent studies have shown that host modulation therapy (HMT) together with traditional mechanical and surgical treatment not only cease the progression of periodontitis but also reduce the systemic collagenolytic biomarkers in both oral fluids and circulation. This suggests that the corresponding adjunctive HMT-medication could be effective in the prevention and treatment of dental peri-implantitis, as well. Furthermore, low-cost, safe, and practical oral fluid active matrix metalloproteinase-8 (aMMP-8) lateral-flow immunotests have been proposed as point-of-care/chair-side diagnostic tools to detect peri-implantitis and periodontitis, and to monitor their effective resolutions, while using various therapeutic strategies, including host modulation. This study reports the potential benefits of HMT-medication in the prevention and treatment of dental peri-implantitis among five patients (four of five were current/ex-smokers). In addition, the aMMP-8 point-of-care test diagnosed 20 peri-implantitis and 20 healthy controls correctly. In conclusion, this study and previous studies support the potential effectiveness of HMT-medication(s) and point-of-care/chair-side technologies in the treatment and diagnostics/monitoring of peri-implantitis. However, more studies are needed to further confirm this.
Subject: peri-implantitis
matrix metalloproteinase 8
point-of-care testing
treatment outcome
116 Chemical sciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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