Mechanical Forces in the Skin : Roles in Tissue Architecture, Stability, and Function

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Biggs , L C , Kim , C S , Miroshnikova , Y A & Wickström , S A 2020 , ' Mechanical Forces in the Skin : Roles in Tissue Architecture, Stability, and Function ' , Journal of Investigative Dermatology , vol. 140 , no. 2 , pp. 284-290 . https://doi.org/10.1016/j.jid.2019.06.137

Title: Mechanical Forces in the Skin : Roles in Tissue Architecture, Stability, and Function
Author: Biggs, Leah C.; Kim, Christine S.; Miroshnikova, Yekaterina A.; Wickström, Sara A.
Contributor organization: Helsinki Institute of Life Science HiLIFE
STEMM - Stem Cells and Metabolism Research Program
Faculty of Medicine
University of Helsinki
Research Programs Unit
Date: 2020-02
Language: eng
Number of pages: 7
Belongs to series: Journal of Investigative Dermatology
ISSN: 0022-202X
DOI: https://doi.org/10.1016/j.jid.2019.06.137
URI: http://hdl.handle.net/10138/317802
Abstract: Tissue shape emerges from the collective mechanical properties and behavior of individual cells and the ways by which they integrate into the surrounding tissue. Tissue architecture and its dynamic changes subsequently feed back to guide cell behavior. The skin is a dynamic, self-renewing barrier that is subjected to large-scale extrinsic mechanical forces throughout its lifetime. The ability to withstand this constant mechanical stress without compromising its integrity as a barrier requires compartment-specific structural specialization and the capability to sense and adapt to mechanical cues. This review discusses the unique mechanical properties of the skin and the importance of signals that arise from mechanical communication between cells and their environment.
Subject: SERUM RESPONSE FACTOR
TERMINAL DIFFERENTIATION
EPIDERMAL BARRIER
BASEMENT-MEMBRANE
FIBROBLAST HETEROGENEITY
ALPHA-6-BETA-4 INTEGRIN
EPIDERMOLYSIS-BULLOSA
TIGHT JUNCTIONS
CELL-ADHESION
ACTIN
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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