The role of oxytocinergic genes in the intergenerational transmission of parent-child relationship qualities

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Savelieva , K , Hintsanen , M , Dobewall , H , Jokela , M , Pulkki-Råback , L , Elovainio , M , Seppälä , I , Lehtimäki , T , Raitakari , O & Keltikangas-Järvinen , L 2019 , ' The role of oxytocinergic genes in the intergenerational transmission of parent-child relationship qualities ' , Hormones and Behavior , vol. 114 , 104540 . https://doi.org/10.1016/j.yhbeh.2019.06.004

Title: The role of oxytocinergic genes in the intergenerational transmission of parent-child relationship qualities
Author: Savelieva, Kateryna; Hintsanen, Mirka; Dobewall, Henrik; Jokela, Markus; Pulkki-Råback, Laura; Elovainio, Marko; Seppälä, Ilkka; Lehtimäki, Tero; Raitakari, Olli; Keltikangas-Järvinen, Liisa
Contributor organization: Department of Public Health
Department of Psychology and Logopedics
Psychosocial factors and health
Date: 2019-08
Language: eng
Number of pages: 8
Belongs to series: Hormones and Behavior
ISSN: 0018-506X
DOI: https://doi.org/10.1016/j.yhbeh.2019.06.004
URI: http://hdl.handle.net/10138/317807
Abstract: Parenting qualities are known to transmit across generations, but less is known about genetic processes that may modify how strongly parenting quality carries across generations. We examined in prospective data whether oxytocinergic genes of offspring moderate the intergenerational transmission of warm and accepting parent-child relationship qualities. The sample comprised 1167 Finnish parents (G2, 62% female) and their mothers (G1). At the study baseline, G1 mothers (Mage = 38) reported parent-child relationship qualities towards G2 children (age range 3-18). After 28-34 years, G2 offspring reported parent-child relationship qualities towards their own children using the same questionnaire. A cumulative genetic score was computed for G2 by summing up previously identified four alleles associated with non-optimal parenting or social impairments across OXTR (rs1042778, rs2254298, rs53576) and CD38 (rs3796863) genes. Results indicated no interaction effects of G2 cumulative genetic score on the transmission of parent-child relationship qualities. Among single polymorphisms in OXTR, the interaction effects of rs53576 and rs1042778 were found. G1 maternal emotional warmth was associated with higher G2 emotional warmth among G2 participants with the OXTR rs53576 AA/AG genotype, but not among those with the GG genotype. G1 maternal acceptance was associated with higher G2 acceptance among those G2 participants with the OXTR rs1042778 GG/GT genotype, but not among those with the TT genotype. Oxytocinergic genes may influence sensitivity to quality of parent-child relationship, although this needs replication in future studies.
Subject: AFFILIATION
Acceptance
BEHAVIOR
CD38 gene
DIFFERENTIAL-SUSCEPTIBILITY
ENVIRONMENT INTERACTION RESEARCH
Gene-environment (GxE) interaction
INDIVIDUAL-DIFFERENCES
Intergenerational transmission
Oxytocin receptor gene (OXTR)
Parent-child relationship qualities
RISK
Warmth
515 Psychology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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