High Intake of Sugar and the Balance between Pro- and Anti-Inflammatory Gut Bacteria

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http://hdl.handle.net/10138/317813

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Satokari , R 2020 , ' High Intake of Sugar and the Balance between Pro- and Anti-Inflammatory Gut Bacteria ' , Nutrients , vol. 12 , no. 5 , 1348 . https://doi.org/10.3390/nu12051348

Title: High Intake of Sugar and the Balance between Pro- and Anti-Inflammatory Gut Bacteria
Author: Satokari, Reetta
Other contributor: University of Helsinki, Reetta Maria Satokari / Principal Investigator




Date: 2020-05
Language: eng
Number of pages: 4
Belongs to series: Nutrients
ISSN: 2072-6643
DOI: https://doi.org/10.3390/nu12051348
URI: http://hdl.handle.net/10138/317813
Abstract: The so-called Western diet is rich in saturated fat and sugars and poor in plant-derived fibers, and it is associated with an increased risk of metabolic and cardiovascular diseases, as well as chronic (low grade) inflammation. The detrimental effects of poor diet are in part mediated by gut microbiota, whose composition, functionality and metabolic end products respond to dietary changes. Recent studies have shown that high intake of sugars increase the relative abundance of Proteobacteria in the gut, while simultaneously decreasing the abundance of Bacteroidetes, which can mitigate the effects of endotoxin, as well as reinforce gut barrier function. Thus, a high sugar intake may stagger the balance of microbiota to have increased pro-inflammatory properties and decreased the capacity to regulate epithelial integrity and mucosal immunity. Consequently, high dietary sugar can, through the modulation of microbiota, promote metabolic endotoxemia, systemic (low grade) inflammation and the development of metabolic dysregulation and thereby, high dietary sugar may have many-fold deleterious health effects, in addition to providing excess energy.
Subject: glucose
fructose
gut microbiota
inflammation
immunoregulation
Proteobacteria
Enterobacteriaceae
LPS
Bacteroidetes
Bacteroides
MICROBIOTA
HEALTH
DIET
3143 Nutrition
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