All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

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http://hdl.handle.net/10138/317827

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Costa , C , Liu , Z , Martins , J P , Correia , A , Rahikkala , A T A , Li , W , Seitsonen , J , Ruokolainen , J , Hirvonen , S-P , Aguiar- Ricardo , A , Corvo , M L & Santos , H A 2020 , ' All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery ' , Biomaterials Science , vol. 8 , no. 12 , pp. 3270-3277 . https://doi.org/10.1039/D0BM00743A

Title: All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery
Author: Costa, Clarinda; Liu, Zehua; Martins, João Pedro; Correia, Alexandra; Rahikkala, Antti Tuomas Antero; Li, Wei; Seitsonen, Jani; Ruokolainen, Janne; Hirvonen, Sami-Pekka; Aguiar- Ricardo, Ana; Corvo, M. Luísa; Santos, Hélder A.
Contributor organization: Division of Pharmaceutical Chemistry and Technology
Nanomedicines and Biomedical Engineering
Faculty of Pharmacy
Doctoral Programme in Drug Research
Drug Research Program
Polymers
Department of Chemistry
Helsinki One Health (HOH)
Divisions of Faculty of Pharmacy
Helsinki Institute of Life Science HiLIFE, Common
Date: 2020-06-21
Language: eng
Number of pages: 8
Belongs to series: Biomaterials Science
ISSN: 2047-4830
DOI: https://doi.org/10.1039/D0BM00743A
URI: http://hdl.handle.net/10138/317827
Abstract: Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
Subject: BARRIER
BILE-SALTS
CELL
CHITOSAN
DRUG-DELIVERY
LIPOSOMES
MOLECULAR-WEIGHT
NANOPARTICLES
STABILITY
VITRO
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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