All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

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http://hdl.handle.net/10138/317827

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Costa , C , Liu , Z , Martins , J P , Correia , A , Rahikkala , A T A , Li , W , Seitsonen , J , Ruokolainen , J , Hirvonen , S-P , Aguiar- Ricardo , A , Corvo , M L & Santos , H A 2020 , ' All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery ' , Biomaterials Science , vol. 8 , no. 12 , pp. 3270-3277 . https://doi.org/10.1039/D0BM00743A

Title: All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery
Author: Costa, Clarinda; Liu, Zehua; Martins, João Pedro; Correia, Alexandra; Rahikkala, Antti Tuomas Antero; Li, Wei; Seitsonen, Jani; Ruokolainen, Janne; Hirvonen, Sami-Pekka; Aguiar- Ricardo, Ana; Corvo, M. Luísa; Santos, Hélder A.
Contributor: University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Doctoral Programme in Drug Research
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Drug Research Program
University of Helsinki, Polymers
University of Helsinki, Helsinki One Health (HOH)
Date: 2020-06-21
Language: eng
Number of pages: 8
Belongs to series: Biomaterials Science
ISSN: 2047-4830
URI: http://hdl.handle.net/10138/317827
Abstract: Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
Subject: BARRIER
BILE-SALTS
CELL
CHITOSAN
DRUG-DELIVERY
LIPOSOMES
MOLECULAR-WEIGHT
NANOPARTICLES
STABILITY
VITRO
317 Pharmacy
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