Genome-wide changes in genetic diversity in a population of Myotis lucifugus affected by white-nose syndrome

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dc.contributor.author Lilley, Thomas M.
dc.contributor.author Wilson, Ian W.
dc.contributor.author Field, Kenneth A.
dc.contributor.author Reeder, DeeAnn M.
dc.contributor.author Vodzak, Megan E.
dc.contributor.author Turner, Gregory G.
dc.contributor.author Kurta, Allen
dc.contributor.author Blomberg, Anna S.
dc.contributor.author Hoff, Samantha
dc.contributor.author Herzog, Carl
dc.contributor.author Sewall, Brent J.
dc.contributor.author Paterson, Steve
dc.date.accessioned 2020-07-24T10:02:01Z
dc.date.available 2020-07-24T10:02:01Z
dc.date.issued 2020-06
dc.identifier.citation Lilley , T M , Wilson , I W , Field , K A , Reeder , D M , Vodzak , M E , Turner , G G , Kurta , A , Blomberg , A S , Hoff , S , Herzog , C , Sewall , B J & Paterson , S 2020 , ' Genome-wide changes in genetic diversity in a population of Myotis lucifugus affected by white-nose syndrome ' , G3 - Genes genomes genetics , vol. 10 , no. 6 , pp. 2007-2020 . https://doi.org/10.1534/g3.119.400966
dc.identifier.other PURE: 138171858
dc.identifier.other PURE UUID: bba5ba24-608e-4118-915f-2c22a6ca29b9
dc.identifier.other WOS: 000539281600019
dc.identifier.other ORCID: /0000-0001-5864-4958/work/77848435
dc.identifier.uri http://hdl.handle.net/10138/317902
dc.description.abstract Novel pathogens can cause massive declines in populations, and even extirpation of hosts. But disease can also act as a selective pressure on survivors, driving the evolution of resistance or tolerance. Bat white-nose syndrome (WNS) is a rapidly spreading wildlife disease in North America. The fungus causing the disease invades skin tissues of hibernating bats, resulting in disruption of hibernation behavior, premature energy depletion, and subsequent death. We used whole-genome sequencing to investigate changes in allele frequencies within a population of Myotis lucifugus in eastern North America to search for genetic resistance to WNS. Our results show low F-ST values within the population across time, i.e., prior to WNS (Pre-WNS) compared to the population that has survived WNS (Post-WNS). However, when dividing the population with a geographical cut-off between the states of Pennsylvania and New York, a sharp increase in values on scaffold GL429776 is evident in the Post-WNS samples. Genes present in the diverged area are associated with thermoregulation and promotion of brown fat production. Thus, although WNS may not have subjected the entire M. lucifugus population to selective pressure, it may have selected for specific alleles in Pennsylvania through decreased gene flow within the population. However, the persistence of remnant sub-populations in the aftermath of WNS is likely due to multiple factors in bat life history. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof G3 - Genes genomes genetics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject BAT HIBERNACULA
dc.subject BROWN MYOTIS
dc.subject EMERGING INFECTIOUS-DISEASES
dc.subject EVAPORATIVE WATER-LOSS
dc.subject GEOMYCES-DESTRUCTANS
dc.subject Genetic resistance
dc.subject Opportunistic pathogen
dc.subject PATTERNS
dc.subject PSEUDOGYMNOASCUS-DESTRUCTANS
dc.subject RESISTANCE
dc.subject SELECTIVE SWEEP
dc.subject SPREAD
dc.subject Selective pressure
dc.subject white-nose syndrome
dc.subject 1184 Genetics, developmental biology, physiology
dc.title Genome-wide changes in genetic diversity in a population of Myotis lucifugus affected by white-nose syndrome en
dc.type Article
dc.contributor.organization Zoology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1534/g3.119.400966
dc.relation.issn 2160-1836
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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