CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non-Hodgkinʼs lymphoma patients: results of the prospective multicenter Goa study

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Turunen , A , Partanen , A , Valtola , J , Ropponen , A , Siitonen , T , Kuittinen , O , Kuitunen , H , Putkonen , M , Sankelo , M , Keskinen , L , Savolainen , E-R , Pyörälä , M , Kuittinen , T , Silvennoinen , R , Penttilä , K , Sikiö , A , Vasala , K , Mäntymaa , P , Pelkonen , J , Varmavuo , V & Jantunen , E 2020 , ' CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non-Hodgkinʼs lymphoma patients: results of the prospective multicenter Goa study ' , Transfusion , vol. 60 , no. 7 , pp. 1519-1528 . https://doi.org/10.1111/trf.15820

Title: CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non-Hodgkinʼs lymphoma patients: results of the prospective multicenter Goa study
Author: Turunen, Antti; Partanen, Anu; Valtola, Jaakko; Ropponen, Antti; Siitonen, Timo; Kuittinen, Outi; Kuitunen, Hanne; Putkonen, Mervi; Sankelo, Marja; Keskinen, Leena; Savolainen, Eeva-Riitta; Pyörälä, Marja; Kuittinen, Taru; Silvennoinen, Raija; Penttilä, Karri; Sikiö, Anu; Vasala, Kaija; Mäntymaa, Pentti; Pelkonen, Jukka; Varmavuo, Ville; Jantunen, Esa
Other contributor: University of Helsinki, Department of Oncology
University of Helsinki, HYKS erva




Date: 2020-07
Language: eng
Number of pages: 10
Belongs to series: Transfusion
ISSN: 0041-1132
DOI: https://doi.org/10.1111/trf.15820
URI: http://hdl.handle.net/10138/318029
Abstract: BACKGROUND Autologous stem cell transplantation is an established treatment option for patients with multiple myeloma (MM) or non-Hodgkin?s lymphoma (NHL). STUDY DESIGN AND METHODS In this prospective multicenter study, 147 patients with MM were compared with 136 patients with NHL regarding the mobilization and apheresis of blood CD34+ cells, cellular composition of infused blood grafts, posttransplant recovery, and outcome. RESULTS Multiple myeloma patients mobilized CD34+ cells more effectively (6.3???106/kg vs. 3.9???106/kg, p?=?0.001). The proportion of poor mobilizers (peak blood CD34+ cell count 100?days) nonrelapse mortality (NRM; 6% vs. 0%, p?=?0.003). CONCLUSIONS Non-Hodgkin?s lymphoma and MM patients differ in terms of mobilization of CD34+ cells, graft cellular composition, and posttransplant recovery. Thus, the optimal graft characteristics may also be different.
Subject: 3126 Surgery, anesthesiology, intensive care, radiology
STEM-CELL TRANSPLANTATION
PLUS G-CSF
HEMATOPOIETIC STEM
POOR MOBILIZATION
RISK-FACTORS
CYCLOPHOSPHAMIDE
MORTALITY
IMPACT
VOLUME
PLERIXAFOR
3122 Cancers
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