CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non-Hodgkinʼs lymphoma patients: results of the prospective multicenter Goa study

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dc.contributor.author Turunen, Antti
dc.contributor.author Partanen, Anu
dc.contributor.author Valtola, Jaakko
dc.contributor.author Ropponen, Antti
dc.contributor.author Siitonen, Timo
dc.contributor.author Kuittinen, Outi
dc.contributor.author Kuitunen, Hanne
dc.contributor.author Putkonen, Mervi
dc.contributor.author Sankelo, Marja
dc.contributor.author Keskinen, Leena
dc.contributor.author Savolainen, Eeva-Riitta
dc.contributor.author Pyörälä, Marja
dc.contributor.author Kuittinen, Taru
dc.contributor.author Silvennoinen, Raija
dc.contributor.author Penttilä, Karri
dc.contributor.author Sikiö, Anu
dc.contributor.author Vasala, Kaija
dc.contributor.author Mäntymaa, Pentti
dc.contributor.author Pelkonen, Jukka
dc.contributor.author Varmavuo, Ville
dc.contributor.author Jantunen, Esa
dc.date.accessioned 2020-07-30T10:30:01Z
dc.date.available 2020-07-30T10:30:01Z
dc.date.issued 2020-07
dc.identifier.citation Turunen , A , Partanen , A , Valtola , J , Ropponen , A , Siitonen , T , Kuittinen , O , Kuitunen , H , Putkonen , M , Sankelo , M , Keskinen , L , Savolainen , E-R , Pyörälä , M , Kuittinen , T , Silvennoinen , R , Penttilä , K , Sikiö , A , Vasala , K , Mäntymaa , P , Pelkonen , J , Varmavuo , V & Jantunen , E 2020 , ' CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non-Hodgkinʼs lymphoma patients: results of the prospective multicenter Goa study ' , Transfusion , vol. 60 , no. 7 , pp. 1519-1528 . https://doi.org/10.1111/trf.15820
dc.identifier.other PURE: 136124550
dc.identifier.other PURE UUID: e58d0a80-ee65-493d-b50f-d994cf8f09e7
dc.identifier.other RIS: urn:25FE059F9304B389110D8282DAB15616
dc.identifier.other WOS: 000528186700001
dc.identifier.uri http://hdl.handle.net/10138/318029
dc.description.abstract BACKGROUND Autologous stem cell transplantation is an established treatment option for patients with multiple myeloma (MM) or non-Hodgkin?s lymphoma (NHL). STUDY DESIGN AND METHODS In this prospective multicenter study, 147 patients with MM were compared with 136 patients with NHL regarding the mobilization and apheresis of blood CD34+ cells, cellular composition of infused blood grafts, posttransplant recovery, and outcome. RESULTS Multiple myeloma patients mobilized CD34+ cells more effectively (6.3???106/kg vs. 3.9???106/kg, p?=?0.001). The proportion of poor mobilizers (peak blood CD34+ cell count 100?days) nonrelapse mortality (NRM; 6% vs. 0%, p?=?0.003). CONCLUSIONS Non-Hodgkin?s lymphoma and MM patients differ in terms of mobilization of CD34+ cells, graft cellular composition, and posttransplant recovery. Thus, the optimal graft characteristics may also be different. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Transfusion
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject STEM-CELL TRANSPLANTATION
dc.subject PLUS G-CSF
dc.subject HEMATOPOIETIC STEM
dc.subject POOR MOBILIZATION
dc.subject RISK-FACTORS
dc.subject CYCLOPHOSPHAMIDE
dc.subject MORTALITY
dc.subject IMPACT
dc.subject VOLUME
dc.subject PLERIXAFOR
dc.subject 3122 Cancers
dc.title CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non-Hodgkinʼs lymphoma patients: results of the prospective multicenter Goa study en
dc.type Article
dc.contributor.organization Department of Oncology
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization HYKS erva
dc.contributor.organization Hematologian yksikkö
dc.contributor.organization Kymsote – Social and Health Services in Kymenlaakso
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/trf.15820
dc.relation.issn 0041-1132
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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