Rhinoviruses in infancy and risk of immunoglobulin E sensitization

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dc.contributor.author DIABIMMUNE Study Grp
dc.contributor.author Korhonen, Laura
dc.contributor.author Oikarinen, Sami
dc.contributor.author Lehtonen, Jussi
dc.contributor.author Mustonen, Neea
dc.contributor.author Tyni, Iiris
dc.contributor.author Niemelä, Onni
dc.contributor.author Honkanen, Hanna
dc.contributor.author Huhtala, Heini
dc.contributor.author Ilonen, Jorma
dc.contributor.author Hämäläinen, Anu-Maaria
dc.contributor.author Peet, Aleksandr
dc.contributor.author Tillmann, Vallo
dc.contributor.author Siljander, Heli
dc.contributor.author Knip, Mikael
dc.contributor.author Lönnrot, Maria
dc.contributor.author Hyöty, Heikki
dc.contributor.author Härkönen, Taina
dc.contributor.author Ryhänen, Samppa
dc.contributor.author Koski, Katriina
dc.contributor.author Kiviniemi, Minna
dc.contributor.author Ahlfors, Helena
dc.contributor.author Kallionpää, Henna
dc.contributor.author Laajala, Essi
dc.contributor.author Lahesmaa, Riitta
dc.contributor.author Lähdesmäki, Harri
dc.contributor.author Moulder, Robert
dc.contributor.author Nieminen, Janne
dc.contributor.author Ruohtula, Terhi
dc.contributor.author Vaarala, Outi
dc.contributor.author Alahuhta, Kirsi
dc.contributor.author Virtanen, Suvi M.
dc.contributor.author Kondrashova, Anita
dc.date.accessioned 2020-07-31T01:07:11Z
dc.date.available 2021-12-18T03:45:11Z
dc.date.issued 2019-08
dc.identifier.citation DIABIMMUNE Study Grp , Korhonen , L , Oikarinen , S , Lehtonen , J , Mustonen , N , Tyni , I , Niemelä , O , Honkanen , H , Huhtala , H , Ilonen , J , Hämäläinen , A-M , Peet , A , Tillmann , V , Siljander , H , Knip , M , Lönnrot , M , Hyöty , H , Härkönen , T , Ryhänen , S , Koski , K , Kiviniemi , M , Ahlfors , H , Kallionpää , H , Laajala , E , Lahesmaa , R , Lähdesmäki , H , Moulder , R , Nieminen , J , Ruohtula , T , Vaarala , O , Alahuhta , K , Virtanen , S M & Kondrashova , A 2019 , ' Rhinoviruses in infancy and risk of immunoglobulin E sensitization ' , Journal of Medical Virology , vol. 91 , no. 8 , pp. 1470-1478 . https://doi.org/10.1002/jmv.25455
dc.identifier.other PURE: 125767671
dc.identifier.other PURE UUID: 490bf4e5-8e83-4258-a3bf-b15dda4237ff
dc.identifier.other WOS: 000473215200013
dc.identifier.other ORCID: /0000-0003-4431-643X/work/59680177
dc.identifier.other ORCID: /0000-0003-1208-8954/work/59680398
dc.identifier.other ORCID: /0000-0002-2779-3384/work/62281009
dc.identifier.uri http://hdl.handle.net/10138/318042
dc.description.abstract Previous data about the role of viruses in the development of allergic immunoglobulin E (IgE) sensitization are contradictory. The aim of this study was to determine the possible associations between exposure to different viruses (rhinovirus, enterovirus, norovirus, and parechovirus) during the first year of life and IgE sensitization. Viruses were analyzed from stool samples collected monthly from infants participating in a prospective birth cohort study. From that study, 244 IgE sensitized case children and 244 nonsensitized control children were identified based on their allergen-specific IgE antibody levels at the age of 6, 18, and 36 months. Stool samples (n = 4576) from the case and control children were screened for the presence of rhinovirus, enterovirus, norovirus, and parechovirus RNA by reverse transcription quantitative polymerase chain reaction. The study showed that rhinovirus was the most prevalent virus detected, present in 921 (20%) samples. None of the viruses were associated with IgE sensitization in the full cohort but after stratifying by sex, the number of rhinovirus positive samples was inversely associated with IgE sensitization in boys (odds ratio [OR]: 0.81; 95% confidence interval [CI]: 0.69-0.94; P = 0.006). There was also a temporal relation between rhinoviruses and IgE sensitization, as rhinovirus exposure during the first 6 months of life was associated with a reduced risk of subsequent IgE sensitization in boys (OR: 0.76; 95% CI: 0.6-0.94; P = 0.016). In conclusion, early exposure to rhinoviruses was inversely associated with IgE sensitization but this protective association was restricted to boys. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Journal of Medical Virology
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject allergy
dc.subject atopy
dc.subject sex
dc.subject stool
dc.subject virus
dc.subject ALLERGIC SENSITIZATION
dc.subject EARLY-CHILDHOOD
dc.subject ENTEROVIRUS INFECTIONS
dc.subject FECAL SAMPLES
dc.subject ASTHMA
dc.subject CHILDREN
dc.subject ATOPY
dc.subject POPULATION
dc.subject ASSOCIATION
dc.subject DISEASES
dc.subject 3111 Biomedicine
dc.subject 1183 Plant biology, microbiology, virology
dc.title Rhinoviruses in infancy and risk of immunoglobulin E sensitization en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Diabetes and Obesity Research Program
dc.contributor.organization Research Programs Unit
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1002/jmv.25455
dc.relation.issn 0146-6615
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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