Preoperative Radiotherapy Leads to Significant Differences in the Plasma Protein Profile of Rectal Cancer Patients

Show full item record



Permalink

http://hdl.handle.net/10138/318062

Citation

Holm , M , Joenväärä , S , Saraswat , M , Tohmola , T , Ristimäki , A , Renkonen , R & Haglund , C 2020 , ' Preoperative Radiotherapy Leads to Significant Differences in the Plasma Protein Profile of Rectal Cancer Patients ' , Oncology , vol. 98 , no. 7 , pp. 493-500 . https://doi.org/10.1159/000505697

Title: Preoperative Radiotherapy Leads to Significant Differences in the Plasma Protein Profile of Rectal Cancer Patients
Author: Holm, Matilda; Joenväärä, Sakari; Saraswat, Mayank; Tohmola, Tiialotta; Ristimäki, Ari; Renkonen, Risto; Haglund, Caj
Contributor: University of Helsinki, Department of Surgery
University of Helsinki, HUSLAB
University of Helsinki, HUSLAB
University of Helsinki, Department of Pathology
University of Helsinki, HUSLAB
University of Helsinki, HUS Abdominal Center
Date: 2020-07
Language: eng
Number of pages: 8
Belongs to series: Oncology
ISSN: 0030-2414
URI: http://hdl.handle.net/10138/318062
Abstract: Introduction:Colorectal cancer (CRC) is the third most common cancer worldwide, accounting for 10% of the global cancer burden. Rectal cancer accounts for around 30% of CRC cases, and patients with resectable rectal cancer are often given preoperative radiotherapy (PRT) to reduce the rate of local recurrence. The human plasma proteome is an exceptionally complex proteome and ideal to study due to its ability to reflect the presence of diseases such as cancer and the ease of obtaining blood samples. Previous proteomic studies involving rectal cancer patients have mostly focused on the identification of proteins involved in resistance to radiotherapy.Objective:The aim of this study was to investigate the overall effects of PRT on plasma protein expression in rectal cancer patients, as there is a lack of such studies.Methods:Here, we have used mass spectrometry and subsequent statistical analyses to analyze the plasma samples of 30 rectal cancer patients according to PRT status (positive or negative) and tumor stage (II or III).Results and Conclusions:We discovered 42 proteins whose levels differed significantly between stage II and III rectal cancer patients who did or did not receive PRT. This study shows that PRT, although localized to the pelvis, leads to measurable, tumor stage-specific changes in plasma protein expression. Future studies of plasma proteins should, when relevant, take this into account and be aware of the widespread effects that PRT has on the plasma proteome.
Subject: 3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
Colorectal cancer
Plasma
Proteomics
Preoperative radiotherapy
Mass spectrometry
COLON-CANCER
PROTEOMICS
IDENTIFICATION
BIOMARKERS
MS
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Holm_et_al._2020.pdf 287.8Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record