Associations between sleep duration and insulin resistance in European children and adolescents considering the mediating role of abdominal obesity

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dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor.author IDEFICS and I. Family Consortia
dc.contributor.author Thumann, Barbara F.
dc.contributor.author Michels, Nathalie
dc.contributor.author Felső, Regina
dc.contributor.author Kaprio, Jaakko
dc.contributor.author Börnhorst, Claudia
dc.date.accessioned 2020-07-31T11:43:01Z
dc.date.available 2020-07-31T11:43:01Z
dc.date.issued 2020-06-30
dc.identifier.citation IDEFICS and I. Family Consortia , Thumann , B F , Michels , N , Felső , R , Kaprio , J & Börnhorst , C 2020 , ' Associations between sleep duration and insulin resistance in European children and adolescents considering the mediating role of abdominal obesity ' , PLoS One , vol. 15 , no. 6 , 0235049 . https://doi.org/10.1371/journal.pone.0235049 en
dc.identifier.issn 1932-6203
dc.identifier.other PURE: 139947399
dc.identifier.other PURE UUID: ff4d41ae-aa2e-46f1-9527-8a4be6c1d658
dc.identifier.other RIS: urn:554D1FE02547E01B5B0944ED2ED64130
dc.identifier.other WOS: 000546956600006
dc.identifier.uri http://hdl.handle.net/10138/318072
dc.description.abstract Background Short sleep duration has been suggested to lead to insulin resistance both directly by altering glucose metabolism and indirectly through obesity. This study aims to investigate associations between nocturnal sleep duration and insulin resistance considering abdominal obesity as a mediator. Methods We analysed data of 3 900 children aged 2–15 years participating in the second (2009/10) and third (2013/14) examination wave of the European IDEFICS/I.Family study (hereafter referred to as baseline and follow-up). Information on nocturnal sleep duration was collected by questionnaires and age-standardised (SLEEP z-score). The homeostasis model assessment (HOMA) was calculated from fasting insulin and fasting glucose obtained from blood samples; waist circumference (WAIST) was measured with an inelastic tape. HOMA and WAIST were used as indicators for insulin resistance and abdominal obesity, respectively, and transformed to age- and sex-specific z-scores. Cross-sectional and longitudinal associations between SLEEP z-score and HOMA z-score were investigated based on a path model considering WAIST z-score as a mediator adjusting for relevant confounders. Results Cross-sectionally, baseline SLEEP z-score was negatively associated with baseline WAIST z-score (unstandardised effect estimate -0.120, 95% confidence interval [-0.167; -0.073]). We observed no direct effect of baseline SLEEP z-score on baseline HOMA z-score but a negative indirect effect through baseline WAIST z-score (-0.042 [-0.058; -0.025]). Longitudinally, there was no direct effect of baseline SLEEP z-score on HOMA z-score at follow-up but a negative indirect effect through both baseline WAIST z-score and WAIST z-score at follow-up (-0.028 [-0.040; -0.016]). Conclusions Our results do not support the hypothesis of an association between short sleep duration and insulin resistance independent of abdominal obesity. However, longer sleep duration may exert short and long term beneficial effects on insulin resistance through its beneficial effects on abdominal obesity. en
dc.format.extent 19
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights en
dc.subject 3121 Internal medicine en
dc.subject CHILDHOOD OBESITY en
dc.subject CARDIOMETABOLIC RISK en
dc.subject REFERENCE VALUES en
dc.subject SERUM-INSULIN en
dc.subject OVERWEIGHT en
dc.subject INDEXES en
dc.subject GLUCOSE en
dc.subject HEALTH en
dc.subject VALIDATION en
dc.subject SECRETION en
dc.title Associations between sleep duration and insulin resistance in European children and adolescents considering the mediating role of abdominal obesity en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1371/journal.pone.0235049
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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