Antihypertensive drug use and prostate cancer-specific mortality in Finnish men

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Siltari , A , Murtola , T J , Talala , K , Taari , K , Tammela , T L J & Auvinen , A 2020 , ' Antihypertensive drug use and prostate cancer-specific mortality in Finnish men ' , PLoS One , vol. 15 , no. 6 , 0234269 .

Title: Antihypertensive drug use and prostate cancer-specific mortality in Finnish men
Author: Siltari, Aino; Murtola, Teemu J.; Talala, Kirsi; Taari, Kimmo; Tammela, Teuvo L. J.; Auvinen, Anssi
Contributor organization: Department of Pharmacology
Faculty of Medicine
University of Helsinki
HUS Abdominal Center
Urologian yksikkö
Department of Surgery
Helsinki University Hospital Area
Date: 2020-06-29
Language: eng
Number of pages: 15
Belongs to series: PLoS One
ISSN: 1932-6203
Abstract: The aim of this study was to investigate pre- and post-diagnostic use of antihypertensive drugs on prostate cancer (PCa)-specific survival and the initiation of androgen deprivation therapy (ADT). The cohort investigated 8,253 PCa patients with 837 PCa-specific deaths during the median follow-up of 7.6 years after diagnosis. Information on drug use, cancer incidence, clinical features of PCa, and causes of death was collected from Finnish registries. Hazard ratios with 95% confidence intervals were calculated using Cox regression with antihypertensive drug use as a time-dependent variable. Separate analyses were performed on PCa survival related to pre- and post-diagnostic use of drugs and on the initiation of ADT. Antihypertensive drug use overall was associated with an increased risk of PCa-specific death (Pre-PCa: 1.21 (1.04–1.4), Post-PCa: 1.2 (1.02–1.41)). With respect to the separate drug groups, angiotensin II type 1 receptor (ATr) blockers, were associated with improved survival (Post-PCa: 0.81 (0.67–0.99)) and diuretics with an increased risk (Post-PCa: 1.25 (1.05–1.49)). The risk of ADT initiation was slightly higher among antihypertensive drug users as compared to non-users. In conclusion, this study supports anti-cancer effect of ATr blockers on PCa prognosis and this should be investigated further in controlled clinical trials.
Subject: 3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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