dc.contributor.author |
Siltari, Aino |
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dc.contributor.author |
Murtola, Teemu J. |
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dc.contributor.author |
Talala, Kirsi |
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dc.contributor.author |
Taari, Kimmo |
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dc.contributor.author |
Tammela, Teuvo L. J. |
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dc.contributor.author |
Auvinen, Anssi |
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dc.date.accessioned |
2020-07-31T11:48:01Z |
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dc.date.available |
2020-07-31T11:48:01Z |
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dc.date.issued |
2020-06-29 |
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dc.identifier.citation |
Siltari , A , Murtola , T J , Talala , K , Taari , K , Tammela , T L J & Auvinen , A 2020 , ' Antihypertensive drug use and prostate cancer-specific mortality in Finnish men ' , PLoS One , vol. 15 , no. 6 , 0234269 . https://doi.org/10.1371/journal.pone.0234269 |
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dc.identifier.other |
PURE: 139947223 |
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dc.identifier.other |
PURE UUID: cd7ca749-9bea-4345-92e6-c737387c7b6b |
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dc.identifier.other |
RIS: urn:35BBE8FB3F5FA274744974A797A7FC8A |
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dc.identifier.other |
WOS: 000546361900025 |
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dc.identifier.other |
ORCID: /0000-0002-7814-427X/work/78163243 |
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dc.identifier.other |
ORCID: /0000-0002-0077-4896/work/78165028 |
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dc.identifier.uri |
http://hdl.handle.net/10138/318073 |
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dc.description.abstract |
The aim of this study was to investigate pre- and post-diagnostic use of antihypertensive drugs on prostate cancer (PCa)-specific survival and the initiation of androgen deprivation therapy (ADT). The cohort investigated 8,253 PCa patients with 837 PCa-specific deaths during the median follow-up of 7.6 years after diagnosis. Information on drug use, cancer incidence, clinical features of PCa, and causes of death was collected from Finnish registries. Hazard ratios with 95% confidence intervals were calculated using Cox regression with antihypertensive drug use as a time-dependent variable. Separate analyses were performed on PCa survival related to pre- and post-diagnostic use of drugs and on the initiation of ADT. Antihypertensive drug use overall was associated with an increased risk of PCa-specific death (Pre-PCa: 1.21 (1.04–1.4), Post-PCa: 1.2 (1.02–1.41)). With respect to the separate drug groups, angiotensin II type 1 receptor (ATr) blockers, were associated with improved survival (Post-PCa: 0.81 (0.67–0.99)) and diuretics with an increased risk (Post-PCa: 1.25 (1.05–1.49)). The risk of ADT initiation was slightly higher among antihypertensive drug users as compared to non-users. In conclusion, this study supports anti-cancer effect of ATr blockers on PCa prognosis and this should be investigated further in controlled clinical trials. |
en |
dc.format.extent |
15 |
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dc.language.iso |
eng |
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dc.relation.ispartof |
PLoS One |
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dc.rights |
cc_by |
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dc.rights.uri |
info:eu-repo/semantics/openAccess |
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dc.subject |
3122 Cancers |
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dc.subject |
BETA-BLOCKERS |
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dc.subject |
RISK |
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dc.subject |
ASSOCIATION |
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dc.subject |
SURVIVAL |
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dc.subject |
DEATH |
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dc.subject |
3126 Surgery, anesthesiology, intensive care, radiology |
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dc.title |
Antihypertensive drug use and prostate cancer-specific mortality in Finnish men |
en |
dc.type |
Article |
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dc.contributor.organization |
Department of Pharmacology |
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dc.contributor.organization |
Faculty of Medicine |
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dc.contributor.organization |
University of Helsinki |
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dc.contributor.organization |
HUS Abdominal Center |
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dc.contributor.organization |
Clinicum |
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dc.contributor.organization |
Urologian yksikkö |
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dc.contributor.organization |
Department of Surgery |
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dc.contributor.organization |
Helsinki University Hospital Area |
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dc.description.reviewstatus |
Peer reviewed |
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dc.relation.doi |
https://doi.org/10.1371/journal.pone.0234269 |
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dc.relation.issn |
1932-6203 |
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dc.rights.accesslevel |
openAccess |
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dc.type.version |
publishedVersion |
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