Antihypertensive drug use and prostate cancer-specific mortality in Finnish men

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dc.contributor.author Siltari, Aino
dc.contributor.author Murtola, Teemu J.
dc.contributor.author Talala, Kirsi
dc.contributor.author Taari, Kimmo
dc.contributor.author Tammela, Teuvo L. J.
dc.contributor.author Auvinen, Anssi
dc.date.accessioned 2020-07-31T11:48:01Z
dc.date.available 2020-07-31T11:48:01Z
dc.date.issued 2020-06-29
dc.identifier.citation Siltari , A , Murtola , T J , Talala , K , Taari , K , Tammela , T L J & Auvinen , A 2020 , ' Antihypertensive drug use and prostate cancer-specific mortality in Finnish men ' , PLoS One , vol. 15 , no. 6 , 0234269 . https://doi.org/10.1371/journal.pone.0234269
dc.identifier.other PURE: 139947223
dc.identifier.other PURE UUID: cd7ca749-9bea-4345-92e6-c737387c7b6b
dc.identifier.other RIS: urn:35BBE8FB3F5FA274744974A797A7FC8A
dc.identifier.other WOS: 000546361900025
dc.identifier.other ORCID: /0000-0002-7814-427X/work/78163243
dc.identifier.other ORCID: /0000-0002-0077-4896/work/78165028
dc.identifier.uri http://hdl.handle.net/10138/318073
dc.description.abstract The aim of this study was to investigate pre- and post-diagnostic use of antihypertensive drugs on prostate cancer (PCa)-specific survival and the initiation of androgen deprivation therapy (ADT). The cohort investigated 8,253 PCa patients with 837 PCa-specific deaths during the median follow-up of 7.6 years after diagnosis. Information on drug use, cancer incidence, clinical features of PCa, and causes of death was collected from Finnish registries. Hazard ratios with 95% confidence intervals were calculated using Cox regression with antihypertensive drug use as a time-dependent variable. Separate analyses were performed on PCa survival related to pre- and post-diagnostic use of drugs and on the initiation of ADT. Antihypertensive drug use overall was associated with an increased risk of PCa-specific death (Pre-PCa: 1.21 (1.04–1.4), Post-PCa: 1.2 (1.02–1.41)). With respect to the separate drug groups, angiotensin II type 1 receptor (ATr) blockers, were associated with improved survival (Post-PCa: 0.81 (0.67–0.99)) and diuretics with an increased risk (Post-PCa: 1.25 (1.05–1.49)). The risk of ADT initiation was slightly higher among antihypertensive drug users as compared to non-users. In conclusion, this study supports anti-cancer effect of ATr blockers on PCa prognosis and this should be investigated further in controlled clinical trials. en
dc.format.extent 15
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3122 Cancers
dc.subject BETA-BLOCKERS
dc.subject RISK
dc.subject ASSOCIATION
dc.subject SURVIVAL
dc.subject DEATH
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Antihypertensive drug use and prostate cancer-specific mortality in Finnish men en
dc.type Article
dc.contributor.organization Department of Pharmacology
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Clinicum
dc.contributor.organization Urologian yksikkö
dc.contributor.organization Department of Surgery
dc.contributor.organization Helsinki University Hospital Area
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1371/journal.pone.0234269
dc.relation.issn 1932-6203
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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