Infant Immune Response to Respiratory Viral Infections

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http://hdl.handle.net/10138/318088

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Heinonen , S , Rodriguez-Fernandez , R , Diaz , A , Oliva Rodriguez-Pastor , S , Ramilo , O & Mejias , A 2019 , ' Infant Immune Response to Respiratory Viral Infections ' , Immunology and Allergy Clinics of North America , vol. 39 , no. 3 , pp. 361-+ . https://doi.org/10.1016/j.iac.2019.03.005

Title: Infant Immune Response to Respiratory Viral Infections
Author: Heinonen, Santtu; Rodriguez-Fernandez, Rosa; Diaz, Alejandro; Oliva Rodriguez-Pastor, Silvia; Ramilo, Octavio; Mejias, Asuncion
Contributor: University of Helsinki, Clinicum
Date: 2019-08
Number of pages: 17
Belongs to series: Immunology and Allergy Clinics of North America
ISSN: 0889-8561
URI: http://hdl.handle.net/10138/318088
Abstract: Of all respiratory viruses that affect infants, respiratory syncytial virus (RSV) and rhinovirus (RV) represent the leading pathogens causing acute disease (bronchiolitis) and are associated with the development of recurrent wheezing and asthma. The immune system in infants is still developing, and several factors contribute to their increased susceptibility to viral infections. These factors include differences in pathogen detection, weaker interferon responses, lack of immunologic memory toward the invading pathogen, and T-cell responses that are balanced to promote tolerance and restrain inflammation. These aspects are reviewed here with a focus on RSV and RV infections.
Subject: RSV
Rhinovirus
Innate immunity
Adaptive immune response
SYNCYTIAL VIRUS-INFECTION
INTERFERON-GAMMA LEVELS
DISEASE SEVERITY
HUMAN RHINOVIRUS
EARLY-LIFE
NEUTRALIZING ANTIBODY
NASAL SECRETIONS
YOUNG-CHILDREN
NASOPHARYNGEAL SECRETIONS
REDUCES HOSPITALIZATION
3121 Internal medicine
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