Tandem-Mass-Tag based proteomic analysis facilitates analyzing critical factors of porous silicon nanoparticles in determining their biological responses under diseased condition

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http://hdl.handle.net/10138/318168

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Li , Y , Liu , Z , Li , L , Lian , W , He , Y , Khalil , E , Makila , E , Zhang , W , Torrieri , G , Liu , X , Su , J , Xiu , Y , Fontana , F , Salonen , J , Hirvonen , J , Liu , W , Zhang , H , Santos , H A & Deng , X 2020 , ' Tandem-Mass-Tag based proteomic analysis facilitates analyzing critical factors of porous silicon nanoparticles in determining their biological responses under diseased condition ' , Advanced Science , vol. 7 , no. 15 , 2001129 . https://doi.org/10.1002/advs.202001129

Title: Tandem-Mass-Tag based proteomic analysis facilitates analyzing critical factors of porous silicon nanoparticles in determining their biological responses under diseased condition
Author: Li, Yunzhan; Liu, Zehua; Li, Li; Lian, Wenhua; He, Yaohui; Khalil, Elbadry; Makila, Ermei; Zhang, Wenzhong; Torrieri, Giulia; Liu, Xueyan; Su, Jingyi; Xiu, Yuanming; Fontana, Flavia; Salonen, Jarno; Hirvonen, Jouni; Liu, Wen; Zhang, Hongbo; Santos, Hélder A.; Deng, Xianming
Contributor organization: Division of Pharmaceutical Chemistry and Technology
Nanomedicines and Biomedical Engineering
Faculty of Pharmacy
Department of Chemistry
Ion exchange for nuclear waste treatment and for recycling
Drug Research Program
Jouni Hirvonen / Principal Investigator
Helsinki One Health (HOH)
Divisions of Faculty of Pharmacy
Date: 2020-08-07
Language: eng
Number of pages: 12
Belongs to series: Advanced Science
ISSN: 2198-3844
DOI: https://doi.org/10.1002/advs.202001129
URI: http://hdl.handle.net/10138/318168
Abstract: The analysis of nanoparticles' biocompatibility and immunogenicity is mostly performed under a healthy condition. However, more clinically relevant evaluation conducted under pathological condition is less known. Here, the immunogenicity and bio-nano interactions of porous silicon nanoparticles (PSi NPs) are evaluated in an acute liver inflammation mice model. Interestingly, a new mechanism in which PSi NPs can remit the hepatocellular damage and inflammation activation in a surface dependent manner through protein corona formation, which perturbs the inflammation by capturing the pro-inflammatory signaling proteins that are inordinately excreted or exposed under pathological condition, is found. This signal sequestration further attenuates the nuclear factor kappa B pathway activation and cytokines production from macrophages. Hence, the study proposes a potential mechanism for elucidating the altered immunogenicity of nanomaterials under pathological conditions, which might further offer insights to establish harmonized standards for assessing the biosafety of biomaterials in a disease-specific or personalized manner.
Subject: BIOCOMPATIBILITY
BLOOD
FIBRILLATION
IRON-OXIDE NANOPARTICLES
MECHANISMS
OXIDATION
PROTEIN CORONA
R-language
RELEASE
SURFACE
TUMOR-GROWTH
acute liver inflammation
immunogenicity
porous silicon
protein corona
116 Chemical sciences
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess


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